Treatment Schedule
The frontline treatment of WT was according to the NWTS-5 protocol.
Patients with relapsed or refractory WT received AI regimen until
disease progression, unacceptable toxicities or patient withdrawal, but
no more than 8 courses, and were evaluated efficacy every 2 cycles. AI
regimen included doxorubicin hydrochloride liposome
(40mg/m2 per day, D1) and irinotecan
(50mg/m2 per day with 90-min infusion, d1-5), repeated
every 3 weeks. Doxorubicin hydrochloride liposomes should be given
anti-allergic pretreatment (including cimetidine, dexamethasone,
diphenhydramine or phenadryl) half an hour before; atropine should be
given half an hour before irinotecan to prevent choline syndrome.
Written informed consent was obtained from all patients when they began
treatment for AI regimen.