Abstract
We have recorded the Huntington’s disease patient’s gait videos at the5 years. It’s treatment with memantine prevented the progression of Clinical symptom. It is recognized to be improved blood flow image in front-temporal lobe of IMP-SPECT.Keywords: Huntington’s disease, Memantine, SPECT, Alzheimer’s disease,
Videos record
Introduction
Huntington’s disease is characterized by personality changes, such as irritability and restlessness, and mental symptoms, such as hallucinations and delusions. When the personality changes become noticeable, involuntary movements called chorea develop.1 The disease is inherited through autosomal dominance and is caused by the expansion of the CAG repeat sequence inHTT gene coding region. The diagnosis is based on the presence of this extension. The average age at onset of Huntington’s disease is 35 to 44 years. In approximately two-thirds of affected patients, neurological symptoms first develop, but in others, the first symptoms are psychological changes. In the early stage after diagnosis, slight changes appear in eye movements, chorea movements, as do inconspicuous involuntary movements, positioning of the head, depressive symptoms, and irritability.2 Chorea movements can be partially suppressed by haloperidol and tetrabenazine of the monoamine-depleting agent.1
In our case, Huntington’s disease treated with memantine, who did not show rapid progression of neurological symptoms, such as chorea movement and gait balance for 5 years. Furthermore, IMP-SPECT revealed improved blood flow image in the front-temporal lobe by memantine treatment.