Abstract
We have recorded the Huntington’s disease patient’s gait videos at the5
years. It’s treatment with memantine prevented the progression of
Clinical symptom. It is recognized to be improved blood flow image in
front-temporal lobe of IMP-SPECT.Keywords: Huntington’s disease,
Memantine, SPECT, Alzheimer’s disease,
Videos record
Introduction
Huntington’s disease is characterized by personality changes, such as
irritability and restlessness, and mental symptoms, such as
hallucinations and delusions. When the personality changes become
noticeable, involuntary movements called chorea
develop.1 The disease is inherited through autosomal
dominance and is caused by the expansion of the CAG repeat sequence inHTT gene coding region. The diagnosis is based on the presence of
this extension. The average age at onset of Huntington’s disease is 35
to 44 years. In approximately two-thirds of affected patients,
neurological symptoms first develop, but in others, the first symptoms
are psychological changes. In the early stage after diagnosis, slight
changes appear in eye movements, chorea movements, as do inconspicuous
involuntary movements, positioning of the head, depressive symptoms, and
irritability.2 Chorea movements can be partially
suppressed by haloperidol and tetrabenazine of the monoamine-depleting
agent.1
In our case, Huntington’s disease treated with memantine, who did not
show rapid progression of neurological symptoms, such as chorea movement
and gait balance for 5 years. Furthermore, IMP-SPECT revealed improved
blood flow image in the front-temporal lobe by memantine treatment.