An evidence-based, risk-adapted algorithm for antifungal prophylaxis reduces risk for invasive mold infections in children with hematologic malignancies^
Ankhi Dutta, MD, MPH1* and Ashley Ikwuezunma, BS2*; Maria I. Castellanos, MD3; Julienne Brackett, MD3; Kiranmye Reddy, MD3; Priya Mahajan, MD3; Ann M. Marshburn, MD4; Kala Kamdar, MD3; Hana Paek, PharmD5; Debra L. Palazzi, MD, MEd1; Karen R. Rabin, MD, PhD3; Michael E. Scheurer, PhD, MPH3; Maria M. Gramatges, MD, PhD3
*contributed equally
1Department of Pediatrics, Section of Infectious Diseases, Texas Children’s Hospital, Baylor College of Medicine
2University of Texas Medical School, Rio Grande Valley
3Department of Pediatrics, Section of Hematology and Oncology, Texas Children’s Hospital, Baylor College of Medicine
4 Department of Pediatrics, Division of Pediatric Hospital Medicine, UTHealth Science Center
5Department of Pharmacy, Texas Children’s Hospital
Corresponding Author:
Maria Monica Gramatges, MD, PhD
Feigin Tower, Baylor College of Medicine
1102 Bates St, Ste 1200
Houston, TX 77030
(p) 832-824-4678; (e) gramatge@bcm.edu; (f) 832-825-4651
Word Count: (abstract 228 , max 250) (main text 2809 , max 3500)
Number of Tables, Figures, Supporting Information: 6 (5 tables and 1 figure)
Dutta at the IDWeek annual meeting in 2016 (‘Epidemiology, management and outcome of invasive mold infections in pediatric hematological malignancies at a tertiary care center: a 10 year review’), and by Ms. Ikwuezunma at the American Society of Hematology annual meeting in 2020 (‘Antifungal prophylaxis and risk for invasive mold infections in children with hematologic malignancies’).
Running Title: Mold Infections in Pediatric Leukemia and Lymphoma
Keywords: antifungal prophylaxis, leukemia, lymphoma, invasive mold infection
Abbreviations:
ALL acute lymphoblastic leukemia
AML acute myeloid leukemia
EORTC/MSG European Organization for Research and Treatment of Cancer/Mycoses Study Group
HIM Health Information Management
HSCT hematopoietic stem cell transplantation
IFD invasive fungal disease
IMI invasive mold infection
TCH Texas Children’s Hospital