3. Conclusion
Conventional methods for diagnosis of Brucella infections may
need expensive laboratory equipment,
long time to achieve the final
results and skilled personnel to interpret them.
Therefore,
efforts are being made to develop new diagnostic methods with improved
characteristics. Utilization of biosensors can be considered as one of
those promising approaches in this case. Among different types of
biosensors, optical biosensors, seem to be appropriate choices for
detection of Brucellaregarding
their advantages including high sensitivity and specificity, shorter
detection time, and ease of application without the need for
dedicated
equipment. When conjugated with nanoparticles, these benefits are
extended particularly in colormetric methods. In this regard, gold
nanoparticles are mainly employed in colorimetric immunoassays but their
high cost and short lifetime prevent them from being utilized in
laboratories. However, magnetic and silica nanoparticles have advantages
like simple synthesis and cheap production and they can be employed in
optical biosensors to introduce efficient methods for rapid, simple, and
easy detection of Brucella in different types of samples. Such
quick and proper optical methods can
also be applied to identify other infectious bacteria.