5.Conclusion
In the studies investigating the relationship between EMT and prognosis
in LSCCs in the literature, any accepted common evaluation criterion to
determine the expression of EMT markers has not been encountered.
Perhaps for this reason, quite different results were obtained in the
studies. In our study, it was noted that as an EMT-TF, Zeb1 is
associated with tumor stage, LNM, and OS. In addition Zeb1 expression
observed in tumor stroma is also significant for OS. There is a limited
number of studies on Zeb1 expression in LSCCs in the literature. Zeb1
expression in tumor stroma has not been studied so far. For this reason,
we thought that Zeb1 expression in both the tumor stroma, and tumor
should be taken into consideration in the evaluation of EMT in LSCCs and
it would be appropriate to support this suggestion with novel studies.