Abstract
Objective: To investigate the relationship between E-cadherin, Beta-catenin, N-cadherin, ZEB1 and αSMA as eithelial mesenchymal transformation markers with tumor stage, lymph node metastasis (LNM) and overall survival (OS) in laryngeal squamous cell carcinomas (LSCC).
Material and method : A total of 100 cases diagnosed with LSCC in our hospital between 2013-2020 were included in the study. Data about lymphovascular invasion (LVI), perineural invasion (PNI), necrosis and LNM were recorded by evaluating hematoxylin- eosin stained slides. Markers of E-cadherin, beta-catenin, N-cadherin, ZEB1 and αSMA were applied to the sections prepared from paraffin blocks of tumor samples.
Results: Ninety-five male and five female patients were included in the study, and 38 of them exited. The average OS time of the cases was 35.8 months. A significant relationship was observed between OS with advanced tumor stage, presence of LNM and PNI. A significant relationship was found between increased tumor Zeb1 expression and advanced tumor stage. In univariate and multivariate analyses, a significant negative relationship with OS, and increased Zeb1 expression in tumor and tumor stroma was seen. Any relationship was not observed between E-cadherin, beta-catenin, N-cadherin and αSMA and OS. ,