5.Conclusion
In the studies investigating the relationship between EMT and prognosis in LSCCs in the literature, any accepted common evaluation criterion to determine the expression of EMT markers has not been encountered. Perhaps for this reason, quite different results were obtained in the studies. In our study, it was noted that as an EMT-TF, Zeb1 is associated with tumor stage, LNM, and OS. In addition Zeb1 expression observed in tumor stroma is also significant for OS. There is a limited number of studies on Zeb1 expression in LSCCs in the literature. Zeb1 expression in tumor stroma has not been studied so far. For this reason, we thought that Zeb1 expression in both the tumor stroma, and tumor should be taken into consideration in the evaluation of EMT in LSCCs and it would be appropriate to support this suggestion with novel studies.