i) Ibrutinib pre-treatment dose response in 16 h ZIP
Male C57BL/6 mice (8 weeks old) were pre-treated with ibrutinib (0.1, 1 or10 mg·kg-1; p.o.) or vehicle (5% DMSO, 30% cyclodextrin) one hour prior to zymosan challenge (100 ug; i.p.). Peritoneal exudate cells were harvested in ice-cold cell PEC harvest buffer (PBS, 5 mM EDTA) 16 h after zymosan challenge.