Conclusions
The present study demonstrated that a single bolus injection of heparin (100 U/kg) without ACT measurement was an effective and safe intra-procedural anticoagulation regimen in patients with uninterrupted NOACs undergoing CBA, which had a relatively short LA indwelling time. With the current increase in NOAC administration and CBA, our results would be helpful in determining the peri-procedural anticoagulation strategy. Further large-scaled RCTs are required to clarity the uncertainty about an optimal appropriate (intra-procedural anticoagulation management under the condition of uninterrupted NOACs.