Objectives: The aims of this study were to analyze early and late outcomes of TVS and identify predictors of poor prognosis . Methods: Single centre retrospective study with 108 patients who underwent TVS between 2007 and 2016. Most of the patients were female (74.1%), mean age of 65 years; 61,1% were in New York Heart Association class III/IV, with a EuroSCORE II of 7.5%. Univariable and Multivariable analyses were developed to identify predictors of perioperative mortality and morbidity and long-term mortality. Results: In-hospital mortality was 12%. Creatinine clearance was an independent predictor of decreased perioperative mortality. This group had 28.7% rate of major perioperative complications. Systolic pulmonary pressure and obesity were predictors of early morbidity. The 10-year mortality was 29.6%. The survival at 1, 5 and 10 years was 80%, 76% and 45%, respectively. Diabetes Mellitus was a risk factor for long-term mortality and creatinine clearance was a predictor of long-term survival. Need for re-operation was identified in 3.5% of the patients. Conclusions: Patients undergoing TVS have high surgical risk making TVS an operation associated with high mortality and morbidity. This research identifies Diabetes Mellitus, renal function, pulmonary hypertension and obesity as the future challenges in TVS.