References
1. Martinez FD, Wright AL, Taussig LM, Holberg CJ, Halonen M, Morgan WJ.
Asthma and wheezing in the first six years of life. the group health
medical associates. The New England Journal of Medicine. 1995;332:133-8.
2. Oksel C, Granell R, Mahmoud O, Custovic A, Henderson AJ, STELAR,
Breathing Together investigators. Causes of variability in latent
phenotypes of childhood wheeze. J Allergy Clin Immunol
2019;143:1783-1790.e11.
3. Jartti T, Lehtinen P, Vuorinen T, Ruuskanen O. Bronchiolitis: Age and
previous wheezing episodes are linked to viral etiology and atopic
characteristics. Pediatr Infect Dis J 2009;28:311-317.
4. Piippo-Savolainen E, Korppi M. Wheezy babies–wheezy adults? review
on long-term outcome until adulthood after early childhood wheezing.
Acta Paediatr 2008;97:5-11.
5. Marlow R, Finn A, Henderson J. Assessing the association between
bronchiolitis in infancy and recurrent wheeze: A whole english birth
cohort case-control study. Thorax 2019;74:503-505.
6. Stern DA, Morgan WJ, Halonen M, Wright AL, Martinez FD. Wheezing and
bronchial hyper-responsiveness in early childhood as predictors of newly
diagnosed asthma in early adulthood: A longitudinal birth-cohort study.
Lancet 2008;372:1058-1064.
7. Goksor E, Amark M, Alm B, Ekerljung L, Lundback B, Wennergren G. High
risk of adult asthma following severe wheezing in early life. Pediatr
Pulmonol 2015;50:789-797.
8. Sigurs N, Aljassim F, Kjellman B, Robinson PD, Sigurbergsson F,
Bjarnason R, Gustafsson PM. Asthma and allergy patterns over 18 years
after severe RSV bronchiolitis in the first year of life. Thorax
2010;65:1045-1052.
9. Backman K, Piippo-Savolainen E, Ollikainen H, Koskela H, Korppi M.
Increased asthma risk and impaired quality of life after bronchiolitis
or pneumonia in infancy. Pediatr Pulmonol 2014;49:318-325.
10. Lasso-Pirot A, Delgado-Villalta S, Spanier AJ. Early childhood
wheezers: Identifying asthma in later life. J Asthma Allergy
2015;8:63-73.
11. Castro-Rodriguez JA, Forno E, Rodriguez-Martinez CE, Celedon JC.
Risk and protective factors for childhood asthma: What is the evidence?
J Allergy Clin Immunol Pract 2016;4:1111-1122.
12. Kotaniemi-Syrjanen A, Reijonen TM, Korhonen K, Korppi M. Wheezing
requiring hospitalization in early childhood: Predictive factors for
asthma in a six-year follow-up. Pediatr Allergy Immunol 2002;13:418-425.
13. BTS/SIGN 158 British Guideline on the Management of Asthma.
https://www.brit-thoracic.org.uk/quality-improvement/guidelines/asthma/.
Updated 2019. Accessed Oct 24, 2019.
14. Reijonen TM, Korppi M. One-year follow-up of young children
hospitalized for wheezing: The influence of early anti-inflammatory
therapy and risk factors for subsequent wheezing and asthma. Pediatric
Pulmonology 1998;26:113-119.
15. Reijonen TM, Kotaniemi-Syrjanen A, Korhonen K, Korppi M. Predictors
of asthma three years after hospital admission for wheezing in infancy.
Pediatrics 2000;106:1406-1412.
16. Hyvarinen MK, Kotaniemi-Syrjanen A, Reijonen TM, Korhonen K, Korppi
MO. Teenage asthma after severe early childhood wheezing: An 11-year
prospective follow-up. Pediatr Pulmonol 2005;40:316-323.
17. Backman K, Ollikainen H, Piippo-Savolainen E, Nuolivirta K, Korppi
M. Asthma and lung function in adulthood after a viral wheezing episode
in early childhood. Clin Exp Allergy 2018;48:138-146.
18. Reijonen TM, Korppi M, Kuikka L, Savolainen K, Kleemola M, Mononen
I, Remes K. Serum eosinophil cationic protein as a predictor of wheezing
after bronchiolitis. Pediatr Pulmonol 1997;23:397-403.
19. Reijonen TM, Korppi M, Kleemola M, Savolainen K, Kuikka L, Mononen
I, Remes K. Nasopharyngeal eosinophil cationic protein in bronchiolitis:
Relation to viral findings and subsequent wheezing. Pediatr Pulmonol
1997;24:35-41.
20. Kotaniemi-Syrjanen A, Reijonen TM, Romppanen J, Korhonen K,
Savolainen K, Korppi M. Allergen-specific immunoglobulin E antibodies in
wheezing infants: The risk for asthma in later childhood. Pediatrics
2003;111:255.
21. Kotaniemi-Syrjanen A, Vainionpaa R, Reijonen TM, Waris M, Korhonen
K, Korppi M. Rhinovirus-induced wheezing in infancy–the first sign of
childhood asthma? J Allergy Clin Immunol 2003;111:66-71.
22. Quanjer PH, Lebowitz MD, Gregg I, Miller MR, Pedersen OF. Peak
expiratory flow: Conclusions and recommendations of a working party of
the european respiratory society. Eur Respir J Suppl 1997;24:2S-8S.
23. Beasley R, Semprini A, Mitchell EA. Risk factors for asthma: Is
prevention possible? Lancet 2015;386:1075-1085.
24. Finnish Institute for Health and Welfare. Statistical information on
welfare and health in Finland. https://sotkanet.fi/sotkanet/en/ updated
2021. Accessed 1 March 2021.
25. Castro-Rodriguez JA, Cifuentes L, Martinez FD. Predicting asthma
using clinical indexes. Front Pediatr 2019;7:320.
26. Piippo-Savolainen E, Remes S, Korppi M. Does blood eosinophilia in
wheezing infants predict later asthma? A prospective 18-20-year
follow-up. Allergy Asthma Proc 2007;28:163-169.
27. Giavina-Bianchi P, Aun MV, Takejima P, Kalil J, Agondi RC. United
airway disease: Current perspectives. J Asthma Allergy 2016;9:93-100.
28. Liu L, Pan Y, Zhu Y, Song Y, Su X, Yang L, Li M. Association between
rhinovirus wheezing illness and the development of childhood asthma: A
meta-analysis. BMJ Open 2017;7:e013034-013034.
29. Bonnelykke K, Vissing NH, Sevelsted A, Johnston SL, Bisgaard H.
Association between respiratory infections in early life and later
asthma is independent of virus type. J Allergy Clin Immunol
2015;136:81-86.e4.
30. Hisinger-Molkanen H, Pallasaho P, Haahtela T, Lindqvist A, Sovijarvi
A, Piirila P. The increase of asthma prevalence has levelled off and
symptoms decreased in adults during 20 years from 1996 to 2016 in
helsinki, finland. Respir Med 2019;155:121-126.
31. Owens L, Laing IA, Zhang G, Turner S, Le Souef PN. Prevalence of
allergic sensitization, hay fever, eczema, and asthma in a longitudinal
birth cohort. J Asthma Allergy 2018;11:173-180.
Table 1. Current risk factors for asthma among cohort subjects
(n = 49) aged 17–20 years.