A large right atrial thrombus penetrating through a patent
foramen ovale in a patient with Prothrombin G2120 Mutation
Ricardo Patricio Pérez Anderson¹,2 MD, Johannes Boehm,
MD, PhD 1,2, Ruediger Lange MD,
PhD1-3, Ralf Guenzinger MD, PhD1,2
1 Department of Cardiovascular Surgery, German Heart Center Munich,
Technische Universitaet Muenchen, Munich, Germany
2 Insure (Institute for Translational Cardiac Surgery), Department of
Cardiovascular Surgery, German Heart Center Munich, Technische
Universitaet Muenchen, Munich, Germany
3 DZHK (German Center for Cardiovascular Research) partner site Munich
Heart Alliance, Munich, Germany
Corresponding author: Ricardo Patricio Perez Anderson
Department of Cardiovascular Surgery
German Heart Center Munich
Lazarettstraße 36, 80636 Munich, Germany
Phone: +49-89-1218-4111, Fax: +49-89-1218-4123
E-mail: perez@dhm.mhn.de
Data availability statement: Data sharing is not applicable to this
article as no new data were created or analyzed in this study.
Funding statement: None
Conflict of interest disclosure: None
Institutional Review Board approval or waiver: There is no method
section and no data were generated in this case report.
Patient consent statement: There is no method section and no data were
generated in this case report.
Permission to reproduce material from other sources: There was no other
material used in this study.
Clinical trial registration: This case report was no clinical trial
Word Count: 1280
Abstract: The Prothrombin mutation G2021 alone is considered a
minor risk factor for thromboembolism, but thromboembolic events are
more likely in the presence of additional risk factors. We report on a
44-year-old female with an atrial thrombus causing pulmonary embolism
and transiting through a patent foramen ovale. The thrombus was
extracted by open heart operation. The patient had a family history for
thromboembolic events. Further diagnostic after surgery found the
patient positive for the Prothrombin mutation G2021, but not for the
Factor V Leiden mutation. After surgery, a permanent oral
anticoagulation has been started.