Table 1. γ-Carboxylation values for GRP, MGP, and BGLAP with respect to the skin phenotype
This table summarizes VKCFD1 patients with skin symptoms. For patients with a PXE-like phenotype a biallelic reduction of GRP was detected (highlighted in red). Young VKCFD1 patients with markedly reduced levels of γ-carboxylated GRP are expected to develop a PXE-like phenotype later in life (highlighted in blue). Pathogenic variants reported in patients with atypical genotype due to the presence of a WT allele, early age of onset, and slightly decreased levels of GRP γ-carboxylation only (highlighted in Magenta). -, Not analyzed