Table 1. γ-Carboxylation values for GRP, MGP, and BGLAP with
respect to the skin phenotype
This table summarizes VKCFD1 patients with skin symptoms. For patients
with a PXE-like phenotype a biallelic reduction of GRP was detected
(highlighted in red). Young VKCFD1 patients with markedly reduced levels
of γ-carboxylated GRP are expected to develop a PXE-like phenotype later
in life (highlighted in blue). Pathogenic variants reported in patients
with atypical genotype due to the presence of a WT allele, early age of
onset, and slightly decreased levels of GRP γ-carboxylation only
(highlighted in Magenta). -, Not analyzed