Abstract:
Background: This meta-analysis assessed the relationship
between Obstructive Sleep Apnea (OSA) and echocardiographic parameters
of diastolic dysfunction (DD), which are used in the assessment of Heart
Failure with Preserved Ejection Fraction (HFpEF).
Methods: We searched the databases including Ovid MEDLINE, Ovid
Embase Scopus, Web of Science, Google Scholar, and EBSCO CINAHL from
inception up to December 26th, 2020. The search was not restricted to
time, publication status or language. Two independent investigators
screened the identified studies and extracted the data, in duplicate. We
conducted a meta-analysis using RevMan v.5. Risk of bias was assessed
using Cochrane collaboration tools. Comparisons were made between
patients with OSA, diagnosed in-laboratory polysomnography (PSG) or home
sleep apnea testing (HSAT), and patients without OSA in relation to
established markers of diastolic dysfunction.