References
Alexa, A., & Rahnenführer, J. (2020). topGO: Enrichment analysis for gene ontology. R package version 2.40.0.
Altschul, S. F., Gish, W., Miller, W., Myers, E. W., & Lipman, D. J. (1990). Basic local alignment search tool. Journal of Molecular Biology , 215 , 403–410. doi: 10.1016/S0022-2836(05)80360-2
Alvarado, S., Rajakumar, R., Abouheif, E., & Szyf, M. (2015). Epigenetic variation in the Egfr gene generates quantitative variation in a complex trait in ants. Nature Communications ,6 (6513). doi: 10.1038/ncomms7513
Amdam, G. V., Norberg, K., Hagen, A., & Omholt, S. W. (2003). Social exploitation of vitellogenin. Proceedings of the National Academy of Sciences of the United States of America , 100 , 1799–1802. doi: 10.1073/pnas.0333979100
Andrew, S. (2010). FastQC: A quality control tool for high throughput sequence data. Available online at: http://www.bioinformatics.babraham.ac.uk/projects/fastqc/.
Bates, D., Mächler, M., Bolker, B. M., & Walker, S. C. (2015). Fitting linear mixed-effects models using lme4. Journal of Statistical Software , 67 (1). doi: 10.18637/jss.v067.i01
Beekman, M., & Oldroyd, B. P. (2008). When workers disunite: Intraspecific parasitism by eusocial bees. Annual Review of Entomology , 53 , 19–37. doi: 10.1146/annurev.ento.53.103106.093515
Blomquist, G. J., & Bagnères, A.-G. (2010). Insect hydrocarbons: Biology, biochemistry, and chemical ecology . Cambridge University Press.
Bolger, A. M., Lohse, M., & Usadel, B. (2014). Trimmomatic: A flexible trimmer for Illumina sequence data. Bioinformatics , 30 , 2114–2120. doi: 10.1093/bioinformatics/btu170
Bonasio, R. (2012). Emerging topics in epigenetics: Ants, brains, and noncoding RNAs. Annals of the New York Academy of Sciences ,1260 , 14–23. doi: 10.1111/j.1749-6632.2011.06363.x
Bonasio, R. (2014). The role of chromatin and epigenetics in the polyphenisms of ant castes. Briefings in Functional Genomics ,13 , 235–245. doi: 10.1093/bfgp/elt056
Bonasio, R., Zhang, G., Ye, C., Mutti, N. S., Fang, X., Qin, N., … Liebig, J. (2010). Genomic comparison of the antsCamponotus floridanus and Harpegnathos saltator .Science , 329 , 1068–1070. doi: 10.1126/science.1192428
Bowers, E. M., Yan, G., Mukherjee, C., Orry, A., Wang, L., Holbert, M. A., … Cole, P. A. (2010). Virtual ligand screening of the p300/CBP histone acetyltransferase: Identification of a selective small molecule inhibitor. Chemistry and Biology , 17 , 471–482. doi: 10.1016/j.chembiol.2010.03.006
Cardoen, D., Wenseleers, T., Ernst, U. R., Danneels, E. L., Laget, D., De Graaf, D. C., … Verleyen, P. (2011). Genome-wide analysis of alternative reproductive phenotypes in honeybee workers. Molecular Ecology , 20 , 4070–4084. doi: 10.1111/j.1365-294X.2011.05254.x
Choppin, M., Graf, S., Feldmeyer, B., Libbrecht, R., Menzel, F., & Foitzik, S. (2021). Queen and worker phenotypic traits are associated with colony composition and environment in Temnothorax rugatulus(Hymenoptera: Formicidae), an ant with alternative reproductive strategies. Myrmecological News , 31 , 61–69. doi: 10.25849/myrmecol.news
Cini, A. (2014). Reliability of yellow bodies as indexes of egg laying activity in the primitively eusocial wasp Polistes dominula .Redia Giornale Di Zoologia , 97 , 183–188.
DeVeale, B., Brummel, T., & Seroude, L. (2004). Immunity and aging: The enemy within? Aging Cell , 3 , 195–208. doi: 10.1111/j.1474-9728.2004.00106.x
dos Santos Conceição Lopes, B., Campbell, A. J., & Contrera, F. A. L. (2020). Queen loss changes behavior and increases longevity in a stingless bee. Behavioral Ecology and Sociobiology ,74 (35). doi: 10.1007/s00265-020-2811-8
Endler, A., Liebig, J., Schmitt, T., Parker, J. E., Jones, G. R., Schreier, P., & Hölldobler, B. (2004). Surface hydrocarbons of queen eggs regulate worker reproduction in a social insect. Proceedings of the National Academy of Sciences of the United States of America ,101 , 2945–2950. doi: 10.1073/pnas.0308447101
Feldmeyer, B., Elsner, D., & Foitzik, S. (2014). Gene expression patterns associated with caste and reproductive status in ants: Worker-specific genes are more derived than queen-specific ones.Molecular Ecology , 23 , 151–161. doi: 10.1111/mec.12490
Foster, K. R., & Ratnieks, F. L. W. (2000). Facultative worker policing in a wasp. Nature , 407 , 692–693. doi: 10.1038/35037665
Garschall, K., & Flatt, T. (2018). The interplay between immunity and aging in Drosophila [version 1; referees: 2 approved].F1000Research , 7 (160). doi: 10.12688/f1000research.13117.1
Giehr, J., Senninger, L., Ruhland, K., & Heinze, J. (2020). Ant workers produce males in queenless parts of multi-nest colonies.Scientific Reports , 10 (2152). doi: 10.1038/s41598-020-58830-w
Giehr, J., Wallner, J., Senninger, L., Ruhland, K., Krüger, T., & Heinze, J. (2020). Substantial direct fitness gains of workers in a highly eusocial ant. Molecular Ecology , 29 , 3720–3730. doi: 10.1111/mec.15586
Glastad, K. M., Graham, R. J., Ju, L., Roessler, J., Brady, C. M., & Berger, S. L. (2019). Epigenetic regulator CoREST controls social behavior in ants. Molecular Cell , 77 , 1–14. doi: 10.1016/j.molcel.2019.10.012
Grodzicki, P., Piechowicz, B., & Caputa, M. (2020). The effect of the queen’s presence on thermal behavior and locomotor activity of small groups of worker honey bees. Insects , 11 (464). doi: 10.3390/insects11080464
Haas, B. J., Papanicolaou, A., Yassour, M., Grabherr, M., Philip, D., Bowden, J., … Regev, A. (2013). De novo transcript sequence reconstruction from RNA-Seq: Reference generation and analysis with Trinity. Nature Protocols , 8 (8). doi: 10.1038/nprot.2013.084.De
Hamilton, W. D. (1964). The genetical evolution of social behavior. II.Journal of Theoretical Biology , 7 , 17–52. doi: 10.4324/9780203790427-5
Hartfelder, K. (2000). Insect juvenile hormone: From “status quo” to high society. Brazilian Journal of Medical and Biological Research , 33 , 157–177. doi: 10.1590/S0100-879X2000000200003
Hartig, F. (2020). DHARMa: residual diagnostics for hierarchical (multi-Level / mixed) regression models. R package version 0.3.1. https://CRAN.R-project.org/package=DHARMa.
Heinze, J. (2008). Hierarchy length in orphaned colonies of the antTemnothorax nylanderi . Naturwissenschaften , 95 , 757–760. doi: 10.1007/s00114-008-0375-y
Heinze, J., Hölldobler, B., & Trenkle, S. (1995). Reproductive behavior of the ant Leptothorax (Dichothorax) pergandei .Insectes Sociaux , 42 , 309–315. doi: 10.1007/BF01240425
Heinze, J., & Schrempf, A. (2008). Aging and reproduction in social insects - A mini-review. Gerontology , 54 , 160–167. doi: 10.1159/000122472
Heinze, J., Stengl, B., & Sledge, M. F. (2002). Worker rank, reproductive status and cuticular hydrocarbon signature in the ant,Pachycondyla cf. inversa . Behavioral Ecology and Sociobiology , 52 , 59–65. doi: 10.1007/s00265-002-0491-1
Herb, B. R. (2014). Epigenetics as an answer to Darwin’s “special difficulty.” Frontiers in Genetics , 5 (321). doi: 10.3389/fgene.2014.00321
Hölldobler, B., & Wilson, E. O. (1990). The ants . Harvard University Press, Cambridge, Massachusetts.
Kim, D., Langmead, B., & Salzberg, S. L. (2015). HISAT: A fast spliced aligner with low memory requirements. Nature Methods ,12 (4). doi: 10.1038/nmeth.3317
Kirfel, P., Kessel, T., Skaljac, M., Seip, M., & Vilcinskas, A. (2020). Inhibition of histone acetylation and deacetylation enzymes affects longevity, development, and fecundity in the pea aphid (Acyrthosiphon pisum ). Archives of Insect Biochemistry and Physiology , 103 (e21614). doi: 10.1002/arch.21614
Kleeberg, I., Menzel, F., & Foitzik, S. (2017). The influence of slavemaking lifestyle, caste and sex on chemical profiles inTemnothorax ants: Insights into the evolution of cuticular hydrocarbons. Proceedings of the Royal Society B: Biological Sciences , 284 (20162249). doi: 10.1098/rspb.2016.2249
Kohlmeier, P., Feldmeyer, B., & Foitzik, S. (2018). Vitellogenin-like A–associated shifts in social cue responsiveness regulate behavioral task specialization in an ant. PLoS Biology , 16 (e2005747). doi: 10.1371/journal.pbio.2005747
Kohlmeier, P., Negroni, M. A., Kever, M., Emmling, S., Stypa, H., Feldmeyer, B., & Foitzik, S. (2017). Intrinsic worker mortality depends on behavioral caste and the queens’ presence in a social insect.Science of Nature , 104 (34). doi: 10.1007/s00114-017-1452-x
Kolder, R. (2012). Pheatmap: pretty heatmaps, R package version 1.0.12 (https:// CRAN.R-project.org/package=pheatmap).
Konrad, M., Pamminger, T., & Foitzik, S. (2012). Two pathways ensuring social harmony. Naturwissenschaften , 99 , 627–636. doi: 10.1007/s00114-012-0943-z
Korb, J. (2016). Why do social insect queens live so long? Approaches to unravel the sociality-aging puzzle. Current Opinion in Insect Science , 16 , 104–107. doi: 10.1016/j.cois.2016.06.004
Kovarova, J., Pountain, A. W., Wildrige, D., Weidt, S., Bingaud, F., Burchmore, R. J. S., … Barrett, M. P. (2018). Deletion of transketolase triggers a stringent metabolic response in promastigotes and loss of virulence in amastigotes of Leishmania mexicana .PLoS Pathogens , 14 (3). doi: 10.1093/nar/gks1004
Li, H., Handsaker, B., Wysoker, A., Fennell, T., Ruan, J., Homer, N., … Sam, T. (2009). The Sequence Alignment / Map format and SAMtools. Bioinformatics , 25 (16). doi: 10.1093/bioinformatics/btp352
Libbrecht, R., Nadrau, D., & Foitzik, S. (2020). A role of histone acetylation in the regulation of circadian rhythm in ants.IScience , 23 (100846). doi: 10.1016/j.isci.2020.100846
Love, M. I., Huber, W., & Anders, S. (2014). Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biology , 15 (550). doi: 10.1186/s13059-014-0550-8
Ma, P., Pan, H., Montgomery, R. L., Olson, E. N., & Schultz, R. M. (2012). Compensatory functions of histone deacetylase 1 (HDAC1) and HDAC2 regulate transcription and apoptosis during mouse oocyte development. Proceedings of the National Academy of Sciences of the United States of America , 109 (8). doi: 10.1073/pnas.1118403109
Majoe, M., Libbrecht, R., Foitzik, S., & Nehring, V. (2021). Queen loss increases worker survival in leaf-cutting ants under paraquat-induced oxidative stress. Philosophical Transactions of the Royal Society B , 376 (20190735). doi: 10.1098/rstb.2019.0735
Maleszka, R. (2016). Epigenetic code and insect behavioural plasticity.Current Opinion in Insect Science , 15 , 45–52. doi: 10.1016/j.cois.2016.03.003
Marshall, H., Lonsdale, Z. N., & Mallon, E. B. (2019). Methylation and gene expression differences between reproductive and sterile bumblebee workers. Evolution Letters , 3 (5), 485–499. doi: 10.1002/evl3.129
Matsuura, K., Himuro, C., Yokoi, T., Yamamoto, Y., Vargo, E. L., & Keller, L. (2010). Identification of a pheromone regulating caste differentiation in termites. Proceedings of the National Academy of Sciences of the United States of America , 107 (29). doi: 10.1073/pnas.1004675107
Monnin, T. (2006). Chemical recognition of reproductive status in social insects. Finnish Zoological and Botanical Publishing Board ,43 , 515–530.
Monnin, T., & Peeters, C. (1999). Dominance hierarchy and reproductive conflicts among subordinates in a monogynous queenless ant.Behavioral Ecology , 10 (3). doi: 10.1093/beheco/10.3.323
Monroy Kuhn, J. M., & Korb, J. (2016). Editorial overview: Social insects: aging and the re-shaping of the fecundity/longevity trade-off with sociality. Current Opinion in Insect Science ,16 (vii–x). doi: 10.1016/j.cois.2016.06.002
Morandin, C., Havukainen, H., Kulmuni, J., Dhaygude, K., Trontti, K., & Helanterä, H. (2014). Not only for egg yolk-functional and evolutionary insights from expression, selection, and structural analyses ofFormica ant vitellogenins. Molecular Biology and Evolution , 31 (8). doi: 10.1093/molbev/msu171
Moritz, R. F. A., & Sakofsky, F. (1991). The role of the queen in circadian rhythms of honeybees (Apis mellifera L.).Behavioral Ecology and Sociobiology , 29 , 361–365. doi: 10.1007/BF00165961
Negroni, M. A., Foitzik, S., & Feldmeyer, B. (2019). Long-livedTemnothorax ant queens switch from investment in immunity to antioxidant production with age. Scientific Reports , 9 , 7270. doi: 10.1038/s41598-019-43796-1
Negroni, M. A., Macit, M. N., Stoldt, M., Feldmeyer, B., & Foitzik, S. (2021). Molecular regulation of lifespan extension in fertile ant worker. Philosophical Transactions of the Royal Society B ,376 (20190736). doi: 10.1098/rstb.2019.0736
Negroni, M. A., Segers, F. H. I. D., Vogelweith, F., & Foitzik, S. (2020). Immune challenge reduces gut microbial diversity and triggers fertility-dependent gene expression changes in a social insect.BMC Genomics , 21 (816). doi: 10.1186/s12864-020-07191-9
Okonechnikov, K., Conesa, A., & García-Alcalde, F. (2016). Qualimap 2: Advanced multi-sample quality control for high-throughput sequencing data. Bioinformatics , 32 (2). doi: 10.1093/bioinformatics/btv566
Oldroyd, B. P., Halling, L. A., Good, G., Wattanachaiyingcharoen, W., Barton, A. B., Nanork, P., … Ratnieks, F. L. W. (2001). Worker policing and worker reproduction in Apis cerana . Behavioral Ecology and Sociobiology , 50 (4). doi: 10.1007/s002650100376
Orr, W. C., & Sohal, R. S. (1994). Extension of life-span by overexpression of superoxide dismutase and catalase in Drosophila melanogaster . Science , 263 (5150). doi: 10.1126/science.8108730
Parker, J. D. (2010). What are social insects telling us about aging?Myrmecological News , 13 , 103–110.
Peeters, C., & Tinaut, A. (2014). Reconstructing life history in ants: Ergatoid queens, facultative monogyny, anddependent colony foundation inMonomorium algiricum (Hymenoptera: Formicidae).Myrmecological News , 20 , 77–85. doi: 10.5281/zenodo.844253
Pertea, M., Pertea, G. M., Antonescu, C. M., Chang, T.-C., Mendell, J. T., & Salzberg, S. L. (2015). StringTie enables improved reconstruction of a transcriptome from RNA-seq reads. Nature Biotechnology ,33 (3). doi: 10.1038/nbt.3122
Quevillon, E., Silventoinen, V., Pillai, S., Harte, N., Mulder, N., Apweiler, R., & Lopez, R. (2005). InterProScan: Protein domains identifier. Nucleic Acids Research , 33 , W116–W120. doi: 10.1093/nar/gki442
R Core Team. (2020). R: a language and environment for statistical computing. R foundation for statistical computing, Vienna, Austria. URL https://www.R-project.org/.
Rogina, B., & Helfand, S. L. (2013). Indy mutations andDrosophila longevity. Frontiers in Genetics , 4 (47). doi: 10.3389/fgene.2013.00047
Ruhland, F., Moulin, M., Choppin, M., Meunier, J., & Lucas, C. (2020). Reproductives and eggs trigger worker vibration in a subterranean termite. Ecology and Evolution , 00 , 1–7. doi: 10.1002/ece3.6325
Rüppell, O., Heinze, J., & Hölldobler, B. (1998). Size-dimorphism in the queens of the North American ant Leptothorax rugatulus(Emery). Insectes Sociaux , 45 , 67–77. doi: 10.1007/s000400050069
Rüppell, O., Heinze, J., & Hölldobler, B. (2001). Alternative reproductive tactics in the queen-size-dimorphic ant Leptothorax rugatulus (Emery) and their consequences for genetic population structure. Behavioral Ecology and Sociobiology , 50 , 189–197. doi: 10.1007/s002650100359
Sampayo, J. N., Olsen, A., & Lithgow, G. J. (2003). Oxidative stress inCaenorhabditis elegans : Protective effects of superoxide dismutase/catalase mimetics. Aging Cell , 2 , 319–326. doi: 10.1046/j.1474-9728.2003.00063.x
Schenk, G., Duggleby, R. G., & Nixon, P. F. (1998). Properties and functions of the thiamin diphosphate dependent enzyme transketolase.International Journal of Biochemistry and Cell Biology ,30 , 1297–1318. doi: 10.1016/S1357-2725(98)00095-8
Schrempf, A., Giehr, J., Röhrl, R., Steigleder, S., & Heinze, J. (2017). Royal Darwinian demons: Enforced changes in reproductive efforts do not affect the life expectancy of ant queens. The American Naturalist , 189 (4). doi: 10.1086/691000
Seehuus, S. C., Norberg, K., Gimsa, U., Krekling, T., & Amdam, G. V. (2006). Reproductive protein protects functionally sterile honey bee workers from oxidative stress. Proceedings of the National Academy of Sciences of the United States of America , 103 (4). doi: 10.1073/pnas.0502681103
Simola, D. F., Graham, R. J., Brady, C. M., Enzmann, B. L., Desplan, C., Ray, A., … Berger, S. L. (2016). Epigenetic (re)programming of caste-specific behavior in the ant Camponotus floridanus .Science , 351 (6268). doi: 10.1126/science.aac6633
Simola, D. F., Ye, C., Mutti, N. S., Doleza, K., Bonasio, R., Liebig, J., … Berger, S. L. (2013). A chromatin link to caste identity in the carpenter ant. Genome Research , 23 , 486–496. doi: 10.1101/gr.148361.112.486
Smith-Unna, R., Boursnell, C., Patro, R., Hibberd, J. M., & Kelly, S. (2016). TransRate: Reference-free quality assessment of de novo transcriptome assemblies. Genome Research , 26 , 1134–1144. doi: 10.1101/gr.196469.115
Spannhoff, A., Kim, Y. K., Raynal, N. J. M., Gharibyan, V., Su, M. B., Zhou, Y. Y., … Bedford, M. T. (2011). Histone deacetylase inhibitor activity in royal jelly might facilitate caste switching in bees. EMBO Reports , 12 (3). doi: 10.1038/embor.2011.9
Taylor, B. A., Cini, A., Sumner, S., Wyatt, C. D. R., & Reuter, M. (2021). The molecular basis of socially mediated phenotypic plasticity in a eusocial paper wasp. Nature Communications , 12 (775). doi: 10.1038/s41467-021-21095-6
Vaiserman, A. (2015). Developmental epigenetic programming of caste-specific differences in social insects: An impact on longevity.Current Aging Science , 7 , 176–186. doi: 10.2174/1874609807666141129173749
Vaiserman, A., Lushchak, O. V., & Koliada, A. K. (2018). Epigenetics of longevity in social insects. In Epigenetics of Aging and Longevity (pp. 271–289). Elsevier Inc. doi: 10.1016/b978-0-12-811060-7.00013-9
Valanne, S., Wang, J.-H., & Rämet, M. (2011). The DrosophilaToll signaling pathway. The Journal of Immunology , 186 , 649–656. doi: 10.4049/jimmunol.1002302
Van Oystaeyen, A., Oliveira, R. C., Holman, L., van Zweden, J. S., Romero, C., Oi, C. A., … Wenseleers, T. (2014). Conserved class of queen pheromones stops social insect workers from reproducing.Science , 343 , 287–290. doi: 10.1126/science.1244899
Villanueva-Segura, O. K., Gómez-Govea, M. A., Garza-Veloz, I., González-Alvarez, R., Carrillo-Gaytán, D., Ramírez-Valles, E. G., … Guzmán-Velasco, A. (2020). Molecular description of proclotting enzyme: a power tool for insect biological control of Aedes aegypti L. Southwestern Entomologist , 45 (3). doi: 10.3958/059.045.0312
Wang, T., Gao, H., Li, W., & Liu, C. (2019). Essential role of histone replacement and modifications in male fertility. Frontiers in Genetics , 10 (962). doi: 10.3389/fgene.2019.00962
Wickham, H. (2010). ggplot2: Elegant graphics for data analysis.Journal of Statistical Software , 35 (1). doi: 10.1007/978-0-387-98141-3
Wojciechowski, M., Lowe, R., Maleszka, J., Conn, D., Maleszka, R., & Hurd, P. J. (2018). Phenotypically distinct female castes in honey bees are defined by alternative chromatin states during larval development.Genome Research , 28 , 1532–1542. doi: 10.1101/gr.236497.118
Wurm, Y., Wang, J., & Keller, L. (2010). Changes in reproductive roles are associated with changes in gene expression in fire ant queens.Molecular Ecology , 19 , 1200–1211. doi: 10.1111/j.1365-294X.2010.04561.x
Xu, I. M. J., Lai, R. K. H., Lin, S. H., Tse, A. P. W., Chiu, D. K. C., Koh, H. Y., … Ng, I. O. L. (2016). Transketolase counteracts oxidative stress to drive cancer development. Proceedings of the National Academy of Sciences of the United States of America ,113 , E725–E734. doi: 10.1073/pnas.1508779113
Yamamoto, R., Bai, H., Dolezal, A. G., Amdam, G., & Tatar, M. (2013). Juvenile hormone regulation of Drosophila aging. BMC Biology , 11 (85). doi: 10.1186/1741-7007-11-85
Yan, H., Bonasio, R., Simola, D. F., Liebig, J., Berger, S. L., & Reinberg, D. (2015). DNA methylation in social insects: How epigenetics can control behavior and longevity. Annual Review of Entomology ,60 , 435–452. doi: 10.1146/annurev-ento-010814-020803
Yoshidas, M. (1990). Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro Trichostatin A*.The Journal of Biological Chemistry , 265 (28). doi: 10.1016/S0021-9258(17)44885-X.
Zhang, J. L., Yuan, X. B., Chen, S. J., Chen, H. H., Xu, N., Xue, W. H., … Xu, H. J. (2018). The histone deacetylase NlHDAC1 regulates both female and male fertility in the brown planthopper,Nilaparvata lugens . Open Biology , 8 (180158). doi: 10.1098/rsob.180158