All patients All patients p value Deceased patients Deceased patients p value
L-TGL (≤ 5.5 g/L) patients H-TGL (> 5.5 g/L) patients L-TGL (≤ 5.5 g/L) patients H-TGL (> 5.5 g/L) patients
DLBCL (n =) 12 84 NA 10 22
Sex (M/F) 7/5 33/51 0.12 6/4 11/11 0.71
Age (years) median [range] 65 [55-80] 70 [21-89] 0.89 65 [57-80] 72 [56-85] 0.41
Lymphoma Ann-Arbor-Stage Lymphoma Ann-Arbor-Stage Lymphoma Ann-Arbor-Stage Lymphoma Ann-Arbor-Stage
I 0 16 0.69 0 0 1
II 1 15 0.69 1 2 1
III 4 15 0.29 2 4 1
IV 7 38 0.60 7 16 1
Central nervous system involvement (CNS) 2 5 0.24 2 1 1
Richter syndrome (RS) 0 2 1 0 2 1
International Prognostic Index (IPI)/Risk group (n=) 10 (CNS excluded) 77 (CNS and RS excluded) 8 (CNS excluded) 19 (CNS and RS excluded)
(0-1) Low 1 7 1 1 0 0.31
(2) Low-Intermediate 2 28 0.72 1 2 1
(3) High-Intermediate 4 19 0.48 2 5 1
(4-5) High 4 23 0.73 4 12 1
Total gammaglobulin level (g/L) median [range] 4.8 [2.7-5.5] 9.15 [5.9-19.3] <0.01 4.78 [2.7-5.5] 9.25 [5.9-19.3] <0.01
Immunoglobulin isotype levels dosage, (n=) 8 46 0.80 7 13 1
IgG level (g/L) median [range] 5.4 [2.8-5.45] 9.6 [6.4-15.7] <0.01 5.45 [2.8-5.45] 11.4 [6.48-13.8] <0.01
IgA level (g/L) median [range] 0.7 [0.35-5.91] 2.3 [0.3-5.0] 0.31 0.61 [0.35-5.91] 1.49 [0.3-2.16] 0.31
IgM level (g/L) median [range] 0.4 [0.2-3.7] 1.0 [0.2-3.3] 0.32 0.46 [0.2-3.7] 1.26 [0.25-1.35] 0.32
CRP level (g/L) median [range] 31 [3-116] 15 [3-237] 0.31 26.5 [3-116] 37 [3-119] 0.31
Ferritin level (µg/L) median [range] 433 [73-1628] 170 [4-3472] 0.02 538.5 [73-1628] 217.5 [93-1496] 0.02
Albumin level (g/L) median [range] 32.5 [24-40.7] 39 [16-50] 0.15 33.8 [24-40.7] 36 [23-46] 0.15
Serum Total protein level (g/L) median [range] 58.17 [46-90] 64.5 [46-72] <0.01 58 [46-90] 63.5 [52-72] 0.24
AG-Ratio median [range] 6.79 [4.62-12.22] 4.39 [1.7-7.13] <0.01 6.79 [4.62-12.22] 4.15 [1.71-7.13] <0.01
LDH (Unit/L) median [range] 341.5 [156-2784] 278 [132-10091] 0.93 285 [156-2784] 366 [162-2793] 0.77
Lymphocytes count (G/L) median [range] 0.8 [0.2-2.58] 1.26 [0.18-7.56] 0.02 0.8 [0.2-2.58] 0.92 [0.27-7.56] 0.27
Follow-up (months), median [range] 15.2 [1.23-57.77] 55.53 [1.17-68.6] <0.001 11.7 [1.23-18.16] 12.18 [1.17-64.23] 0.02
Deaths 10 (83.3%) 22 (26.2%) 0.03 10 (83.3%) 22 (26.2%) 0.03
Causes of deaths Infections DLBCL progression Other causes 10 (100%) 0 (0%) 0 (0%) 6 (27.3%) 12 (54.5%) 4 (18%) <0.001 0.35 1 10 (100%) 0 (0%) 0 (0%) 6 (27.3%) 12 (54.5%) 4 (18%) <0.001 0.35 1