Inclusion and exclusion criteria
This study enrolled 20-80-year-old subjects with mild-to-moderate CTS authenticated by electrophysiological study and symptoms for at least 3 months. Symptoms and signs of CTS included: 1) positive Phalen’s test or Tinel’s sign, 2) decreased sensation with numbness over MN innervated territory of hand, 3) MN innervated thenar muscle weakness or atrophy, and 4) paresthesia, dysesthesia, or pain aggravated by long rest or repeated wrist motion, and relieved by shaking the hand or changing the posture.6, 19 Exclusion criteria included: 1) a previous history of wrist surgery, polyneuropathy, brachial plexopathy, or thoracic outlet syndrome, 2) systematic infection, 3) pregnancy, or 4) previous steroid injection for CTS.