Study design
This prospective, randomized, single-blind controlled study was conducted with the approval of the institutional review board of our institute (No. 2-106-05-042) and was officially listed and accepted at www.ClinicalTrials.gov with the registration number NCT03031041. From January 2017 to August 2019, 50 individuals diagnosed with mild-to-moderate CTS were eligible, and 47 were enrolled in this study. Written informed consent for this trial was received from all the patients. An independent researcher utilized computer-generated randomization (Microsoft Excel) to determine which procedure the patient received. All subjects were block-randomized in a 1:1 ratio.
Both groups underwent one session ultrasound-guided HD with 5 mL of normal saline (NS). Both wrists were allocated to the same group assuming that participants were diagnosed with bilateral CTS and only the most symptomatic side was recorded for analysis. Except for acetaminophen (500 mg, up to 4 g per day), any treatment for CTS was prohibited for 2 weeks before and 6 months after the injection. A research assistant performed regular follow-ups on whether additional therapies were utilized.