Methods
This prospective and randomized study was conducted at the Dept. of Medicine of Hubei Minzu University and Guangxi University of Chinese Medicine, performed for two years from September 2018 to September 2020. The Institutional Review Board and the local ethical committee have approved the study after registration with the Research Center (protocol Gui Ke AD1924518). This study followed the criteria as declared by the ARRIVE guidelines 2.0.