Conclusions
Women with recent GDM are at high risk for progressing to impaired
glucose tolerance and eventually type 2 diabetes. Our model prioritized
the use of information routinely available or easy to collect as part of
routine care and had good predictive ability to identify women at
highest risk of progression. Future research should evaluate, refine,
and externally validate our model in larger cohorts of women with recent
GDM followed for longer periods of time to evaluate the ability to
predict type 2 diabetes. If found to be valid and reliable, a predictive
model to identify women with recent GDM at highest risk to progress to
type 2 diabetes would have important prevention benefits for type 2
diabetes among this high risk population.
Acknowledgements: None declared.
Disclosure of Interests: None declared.
Contribution to authorship: EW designed the study and oversaw
data collection. AMB designed the analysis, with input from ALED and RG,
and drafted the initial manuscript. ALED conducted the data analysis and
helped with drafting the manuscript. All authors critically reviewed and
provided feedback on the final manuscript. AMB takes responsibility for
the contents of the article.
Ethics approval: All study participants provided written
informed consent prior to data collection and ethical approval was
provided by the Institutional Review Board Women and Infants Hospital in
Providence, Rhode Island on January 6, 2016. (IRB #836907)
Funding: This work was supported by the National Institute of
Mental Health (grant number R00 MH112413) and the American Diabetes
Association (grant number 1-16-ICTS-118).