Conclusions
Women with recent GDM are at high risk for progressing to impaired glucose tolerance and eventually type 2 diabetes. Our model prioritized the use of information routinely available or easy to collect as part of routine care and had good predictive ability to identify women at highest risk of progression. Future research should evaluate, refine, and externally validate our model in larger cohorts of women with recent GDM followed for longer periods of time to evaluate the ability to predict type 2 diabetes. If found to be valid and reliable, a predictive model to identify women with recent GDM at highest risk to progress to type 2 diabetes would have important prevention benefits for type 2 diabetes among this high risk population.
Acknowledgements: None declared.
Disclosure of Interests: None declared.
Contribution to authorship: EW designed the study and oversaw data collection. AMB designed the analysis, with input from ALED and RG, and drafted the initial manuscript. ALED conducted the data analysis and helped with drafting the manuscript. All authors critically reviewed and provided feedback on the final manuscript. AMB takes responsibility for the contents of the article.
Ethics approval: All study participants provided written informed consent prior to data collection and ethical approval was provided by the Institutional Review Board Women and Infants Hospital in Providence, Rhode Island on January 6, 2016. (IRB #836907)
Funding: This work was supported by the National Institute of Mental Health (grant number R00 MH112413) and the American Diabetes Association (grant number 1-16-ICTS-118).