Statistical analysis
SPPS 25 [IBM Corp. Released 2017. IBM SPSS Statistics for Windows, Version 25.0. Armonk, NY: IBM Corp.] statistical package program was used to evaluate the data. Histopathological changes between experimental groups were analyzed comparatively. Experiments were done independently in 6 replicates. Variables are expressed using mean ± standard deviation, percentage and frequency values. Variables were evaluated after checking the preconditions for normality and homogeneity of variances [Shapiro Wilk and Levene Test]. For comparison of three or more groups, the one-way anova test and the Tukey HSD test, one of the multiple comparison tests, were used. Categorical data were analyzed with Fisher’s Exact Test and Chi-Square test. In cases where the expected frequencies are lower than 20%, an evaluation was made with the ”Monte Carlo Simulation Method” to include these frequencies in the analysis. For the significance level of the tests, p <0.05 and p <0.01 values were accepted.