2.8 Statistical analysis
Data from in vitro experiments were reported as mean and standard deviation. Paired t-test was used to analyse the differences between treated and untreated cell samples. An analysis-of-variance (ANOVA), accounting for correlation within matched pairs, was used to explore concentration-response relationships. P-values < 0.05 were considered statistically significant. Data from in vivoexperiments are reported as box plots: the horizontal line in the middle of the box marks the median of values; the edges of each box mark the 25th and 75th percentiles and vertical lines, extending up and down from each box, represent respectively largest and smallest values that are not outliers (values greater than 1.5 times the length of the box were considered outliers and excluded from the analysis). Paired t-test was used analyse the differences between treated and untreated groups. P-values<0.05 were considered statistically significant.