2.8 Statistical analysis
Data from in vitro experiments were reported as mean and standard
deviation. Paired t-test was used to analyse the differences between
treated and untreated cell samples. An analysis-of-variance (ANOVA),
accounting for correlation within matched pairs, was used to explore
concentration-response relationships. P-values < 0.05 were
considered statistically significant. Data from in vivoexperiments are reported as box plots: the horizontal line in the middle
of the box marks the median of values; the edges of each box mark the
25th and 75th percentiles and
vertical lines, extending up and down from each box, represent
respectively largest and smallest values that are not outliers (values
greater than 1.5 times the length of the box were considered outliers
and excluded from the analysis). Paired t-test was used analyse the
differences between treated and untreated groups.
P-values<0.05 were considered statistically significant.