2.3 Treatment schedules
The repeated drug therapy of CSDS mice was implemented once daily at 9:30 a.m.—10:30 a.m. in time of the last 14 days. The doses chosen were based on the behavioral consequences and previous records (Xu, Wang, Zhao, Gao, & Cui, 2017). All these compounds were stereotactic injected into the bilateral nucleus accumbens (NAc). Control mice were given the corresponding vehicle, also in the parallel volume.