The primary pathophysiological characteristics of HLH include excessive cytotoxic T cell (CTL) and macrophage activation and expansion. These activated immune cells, in turn, produce excessively high levels of inflammatory cytokines, including IL-1, IL-2, IL-6, IL-10, TNF-α, and IFN-γ, which can promote further CTL and macrophage activation and expansion, thereby exacerbating the ongoing cytokine storm and driving consequent multiple organ failure [2]. On admission, patients present with increased circulating levels of some inflammatory cytokines, such as IL-6, IL-8, IL-10, and IFN-γ, suggesting an ongoing systemic inflammatory reaction. HA330 is a neutral microporous resin column with abundant micropores and a high specific surface area that can efficiently eliminate low molecular weight toxins [10].