Introduction
The effect of novel coronavirus disease 2019 (COVID-19) on pediatric oncology patients is unknown. Early reports from China, Europe, and New York/New Jersey have shown minimal to no risk for morbidity or mortality in children with cancer and have been unable to find significant risk factors for severe disease in this patient population.1,2,3,4,5 Here, we report three patients with pediatric cancer who developed severe cardiorespiratory dysfunction (as defined by evidence of heart failure by echocardiogram and/or intubation secondary to respiratory failure) following COVID-19 infections, with one resultant death. We compared clinical and host factors between these three patients with severe cardiorespiratory symptoms to five patients in active treatment at our institution who tested positive for COVID-19 but did not develop severe cardiorespiratory symptoms.