Effects of microinjection of LY235959 or NBQX into the insular
cortex on the increase in circulating corticosterone evoked by restraint
stress
LY235959 – Bilateral microinjection of the selective NMDA
antagonist LY235959 (1 nmol/100 nL) did not alter the increase in
circulating corticosterone caused by restraint stress (treatment:
F(1,11) = 0.1106; time: F(1, 11) =
22.91; interaction: F(1,11) = 1.168) (Fig. 6). The
baseline corticosterone release (before stress) of animals treated with
LY235959 was not different from that of animals treated with aCSF (t =
1.219).
NBQX – Bilateral microinjection of the selective non-NMDA
antagonist NBQX (1 nmol/100 nL) did not change the increase in
corticosterone triggered by restraint stress (treatment:
F(1,11) = 1.256; time: F(1,11) = 34.61;
interaction: F(1,11) = 1.698) (Fig. 6). NBQX treatment
did not change the baseline corticosterone release (before stress) of
animals treated with NBQX compared to animals treated with aCSF (t =
0.1818).