Acknowledgements
The authors thank Dr Lewis Green (Salford Royal Foundation Trust) assisting with data collation.

Transparency statement

Dr. Heald as corresponding author affirms that this is an honest, accurate, and transparent account of the study being reported; that no important aspects of the study have been omitted; and that any discrepancies from the study as planned (and, if relevant, registered) have been explained.

Ethics Statement

As this project was deemed by our local Research and Development Committee as a quality improvement (QI) project, no individual patient was contacted in the course of the evaluation and data was fully anonymised prior to analysis, it was not felt that formal ethics permission was required.

Funding

We have no external funding to declare.

Role of the Sponsor

There was no research sponsor for this study

Dissemination of study results to participants

Dissemination to interested patient groups both locally and nationally will be done once the analysis has been finalised

Patient Consent

This was not deemed necessary as no individual patient was contacted or asked to do anything beyond their usual clinical care.

Data Availability

We used patient level data which was fully anonymised prior to analysis. Any requests for access to this data should be made to the corresponding author, Dr Adrian Heald.

Duality of interest

No author has anything to disclose in relation to conflict of interest.

Contribution Statement

AHH and AR conceived the study. MM and LM collected the data. MM, AAF and GY conducted the data analysis. CJD, ML and AAF provided perspective from the laboratory. AN assisted with the literature review.
MM, LM, GY, ML, SD, AR, AN, AAF, CJD, PT and AHH all contributed to writing of the paper. AAF, and PT provided an overview of the manuscript.