Offline ICE/IVUS quantitative images analysis
Images were stored and analyzed offline by two independent operators, blinded to clinical and procedural data, at the OxACCT CoreLab (Oxford Academic Cardiovascular CT CoreLab) using QIVUS software (Medis Medical, Leiden, The Netherlands). Images analysis was performed as previously outlined 14,15.
Lumen and vessel diameters, areas and sphericity indexes and wall thickness were measured at the level of the PV ostium as indicated in Figure 1. The PV ostium was identified as point of maximal inflection between LA and PV wall, as previously described16.
Comparisons between corresponding PV measurements obtained from ICE and IVUS frames and between pre- and post-ablation measurements were made. Post-ablation morphological changes of the PV wall such as dissection-like changes were recorded.