Sex-specific differences in adult monocyte ER-β expression in response to ICI 182,780 treatment
We determined the effects of E2, ICI 182,780, or LPS on ER-α or ER-β expression. Neither ER-α or ER-β showed statistically significant differences in expression between the sexes following treatment or overall, however there was a general trend towards higher ER-α and ER-β expression adult females compared to adult males (Figure 2; panels B, D). A statistically significant difference between male versus female adults was observed in ER-β monocyte receptor expression following ICI 182,780 treatment (p<0.05).