Abstract
The rapid spread of the SARS‐CoV‐2 pandemic worldwide and especially in Tunisia poses challenges to the management of both physical and mental health. This unexpected situation could predict multiple cases of psychosis.
However, the psychological impact of the COVID-19 pandemic in patients with genetic diseases such as Tuberous sclerosis complex remains to be misunderstood.
We report a case of a patient with Tuberous sclerosis who presented to the emergency of a Tunisian psychiatric hospital with hallucinations, delusions, and disorganized behavior. He developed psychotic symptoms directly triggered by stress derived from the COVID-19 pandemic.