Psoriasis is one of the most common chronic cutaneous skin disorders, having genetic and immunological components. It is currently unknown what exactly triggers it, or how far reaching are the etiological factors, although great strides have been made in uncovering the pathophysiological cascade. Presently, there is a wide diversity of treatment methods for psoriasis, yet not all are applicable for each patient. Selection of both drug and dosage depends on both the knowledge and experience of the treating dermatologist, but also on the specific characteristics of each patient. Therefore, the treating physicians should be made aware of the management possibilities, their advantages, as well as their side effects. Current therapies are divided into topical, systemic, and biological agents. In the following manuscript, we present an updated version of these therapies, alongside their indications, posology and most common side effects, a guide that may be useful for every practitioner in this field.