Structure dynamics
Some of the most common mutations and their effect on structure were
computed through online DynaMut server [16]. The server implements
normal mode methods, and mutation effect prediction which can be used to
analyze the mutations’ effect on protein stability and flexibility
behind vibrational entropy changes. The impact of a mutation is
predicted through normal mode dynamics and graph-based signatures. This
approach outperforms (P-value < 0.001) and the results are
displayed in good resolution.