Structure dynamics
Some of the most common mutations and their effect on structure were computed through online DynaMut server [16]. The server implements normal mode methods, and mutation effect prediction which can be used to analyze the mutations’ effect on protein stability and flexibility behind vibrational entropy changes. The impact of a mutation is predicted through normal mode dynamics and graph-based signatures. This approach outperforms (P-value < 0.001) and the results are displayed in good resolution.