Title:The
sequential role of Mst1/mTORC1/STAT1 activity in chemokine receptor
2-regulated B cell receptor signaling
Short title : CCR2 regulates BCR signaling
Yingzi Zhu1a, Heng Gu2a,
Lu
Yang2, Na Li3, Qiuyue
Chen4, Danqing Kang2, Yukai
Jing2, Panpan Jiang2, Qianglin
Chen4, Li Luo2, Ju
Liu2, Jiang Chang2, Zhenzhen
Li2, Yi Wang2, Xin
Dai2, Heather
Miller5, Lisa S Westerberg6,
Chan-Sik Park7, Masato Kubo8, Lingli
Dong1*, and Chaohong Liu2*
1Department
of Rheumatology and Immunology, Tongji Hospital, Tongji Medical College,
Huazhong University of Science and Technology, Wuhan, China;
2Department of Pathogen Biology,
Tongji Medical College, Huazhong
University of Science and Technology, Wuhan, China;
3Department of Oncology, First Affiliated Hospital of
Yangtze University, Jingzhou, China;
4Department of Immunology, School of Medicine, Yangtze
University, Jingzhou, China;
5Department of Research and Development, BD
Biosciences, San Jose, CA, United States;
6Department of Microbiology Tumor and Cell Biology,
Karolinska Institutet, Stockholm, Sweden;
7Department of Pathology, Asan Medical Center,
University of Ulsan College of Medicine, 88, Olympic-ro 43-gil,
Songpa-gu, Seoul, 05505, Korea;
8Laboratory for Cytokine Regulation, Center for
Integrative Medical Science (IMS), RIKEN Yokohama Institute, Kanagawa,
Japan.