SMYD4
Nothing is known about the function of SMYD4 in relation to the immune
system, either in health or in disease. There is only one article that
mentions SMYD4 as a methyltransferase upregulated in TNFα-stimulated
synovial fibroblasts from patients with rheumatoid arthritis compared to
equally stimulated synovial fibroblasts from patients with
osteoarthritis. No further insights about the biological meaning of this
alteration in SMYD4 expression are offered by the authors (Araki et al.
2018).