SMYD5
With respect to SMYD5, Stender et al. shed light on its role in the immune system, in particular in macrophages. They demonstrated that SMYD5 is associated with the nuclear receptor corepressor (NCoR) complex and recruited to Toll-like receptor (TLR)4-responsive genes in macrophages, where it actively participates in the basal repression of TLR4-responsive promoters by catalysing histone 4 lysine 20 trimethylation (H4K20me3). When TLR4 is activated, PHD finger protein 2 (PHF2) demethylates H4K20me3 to induce TLR4-dependent gene expression. According to their results, SMYD5 may be a negative regulator of macrophage inflammatory responses (Stender et al. 2012).