SMYD4
Nothing is known about the function of SMYD4 in relation to the immune system, either in health or in disease. There is only one article that mentions SMYD4 as a methyltransferase upregulated in TNFα-stimulated synovial fibroblasts from patients with rheumatoid arthritis compared to equally stimulated synovial fibroblasts from patients with osteoarthritis. No further insights about the biological meaning of this alteration in SMYD4 expression are offered by the authors (Araki et al. 2018).