SMYD5
With respect to SMYD5, Stender et al. shed light on its role in
the immune system, in particular in macrophages. They demonstrated that
SMYD5 is associated with the nuclear receptor corepressor (NCoR) complex
and recruited to Toll-like receptor (TLR)4-responsive genes in
macrophages, where it actively participates in the basal repression of
TLR4-responsive promoters by catalysing histone 4 lysine 20
trimethylation (H4K20me3). When TLR4 is activated, PHD finger protein 2
(PHF2) demethylates H4K20me3 to induce TLR4-dependent gene expression.
According to their results, SMYD5 may be a negative regulator of
macrophage inflammatory responses (Stender et al. 2012).