Conclusions and further directions
Most of the data about SMYD protein function in immunology are related to blood cancers, since the involvement of these methyltransferases in cancer is unquestionable. Nevertheless, basic research regarding their function in immune cells is scarce, with few publications studying macrophages and T cells. Nevertheless, all the data presented in this review (summarised in Table 1 ) indicate that SMYD family members do have relevant functions in immunology, in health and disease, but they need to be further explored. Future research may also assess whether they can be targeted in pathologies in which the immune system is crucial.