Conclusions and further directions
Most of the data about SMYD protein function in immunology are related
to blood cancers, since the involvement of these methyltransferases in
cancer is unquestionable. Nevertheless, basic research regarding their
function in immune cells is scarce, with few publications studying
macrophages and T cells. Nevertheless, all the data presented in this
review (summarised in Table 1 ) indicate that SMYD family
members do have relevant functions in immunology, in health and disease,
but they need to be further explored. Future research may also assess
whether they can be targeted in pathologies in which the immune system
is crucial.