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Research of Occult Hepatitis B Infection in HIV-infected Patients, Schindler Study
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  • Gülten ünlü,
  • yeşim yıldız,
  • Meryem Merve Oren,
  • mehmet çabalak,
  • Ayşe Özlem Mete,
  • Süheyla Kömür,
  • Figen Sarıgül,
  • Dilara Inan,
  • Sibel Altunisik Toplu,
  • Ömer Karaşahin,
  • Yakup Demir,
  • Merve Ayhan,
  • İlkay Karaoğlan,
  • Yesim TASOVA,
  • Yasar Bayindir,
  • Tuba Dal,
  • Mustafa Kemal Çelen
Gülten ünlü
Kocaeli Derince Training and Research Hospital
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yeşim yıldız
²Gazi University Faculty of Medicine Department of Infectious Diseases and Clinical Microbiology, Ankara.
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Meryem Merve Oren
Istanbul University Istanbul Faculty of Medicine, Department of Public Health
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mehmet çabalak
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Ayşe Özlem Mete
Gaziantep University
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Süheyla Kömür
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Figen Sarıgül
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Dilara Inan
Akdeniz University Faculty of Medicine
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Sibel Altunisik Toplu
Inonu Universitesi
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Ömer Karaşahin
Erzurum Bolge Egitim ve Arastirma Hastanesi
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Yakup Demir
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Merve Ayhan
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İlkay Karaoğlan
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Cukurova University Faculty of Medicine
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Yasar Bayindir
Inonu University
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Tuba Dal
Yildirim Beyazit University Faculty of Medicine
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Mustafa Kemal Çelen
Dicle University Medical Faculty
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Research of Occult Hepatitis B Infection in HIV-infected Patients, Schindler Study ABSTRACT Objective: Occult hepatitis B infection seems to be more prevalent among subjects at high risk for HBV infection and with concomitant liver disease. The aim of this study was to assess the prevalence of OHBI in group of HIV-1+/HBsAg- Turkish patients. Methods: Ten centers in Turkey have been included in the study. Gender, age, occupation, place of residence, treatment status, clinic, immunodeficiency panel, eliza tests, hemogram, biochemistry and coagulation laboratory results of the patients were evaluated retrospectively. Results: The number of HIV-infected patients followed in these centers is 3172. The mean age of the patients was 37.2 ± 13.1, and they were 235 males (84.5%) and 43 (15.5%) females. 278 (99.6%) of the patients are patients who received antiretroviral treatment. included in the s Of the 279 patients included in the study, it was determined that HBsAg was negative in all of them, 169 were positive for Anti HBs and 125 were positive for Anti HBc IgG. HIV RNA (203/278) was detected in 203 of the patients. 4 (1.4%) of the patients were diagnosed with OHB. In our study, no significant difference was found in hemoglobin and bilirubin levels and complete blood count in patients with HIV-OHB co-infection. However, albumin values were found to be <3.5 in three OHD patients (p = 0.043). Conclusion: Reasearch the presence of OHB infection in HIV-infected patients is important in determining treatment options and predicting the survival of patient. Hypoalbuminemia could be showing hepatic failure and we can suggest the importance of treatment that diseases.

Peer review status:ACCEPTED

03 Mar 2021Submitted to International Journal of Clinical Practice
05 Mar 2021Submission Checks Completed
05 Mar 2021Assigned to Editor
05 Mar 2021Reviewer(s) Assigned
27 Mar 2021Review(s) Completed, Editorial Evaluation Pending
18 Apr 20211st Revision Received
19 Apr 2021Assigned to Editor
19 Apr 2021Submission Checks Completed
26 Apr 2021Reviewer(s) Assigned
30 Apr 2021Review(s) Completed, Editorial Evaluation Pending
04 May 20212nd Revision Received
05 May 2021Submission Checks Completed
05 May 2021Assigned to Editor
05 May 2021Review(s) Completed, Editorial Evaluation Pending
07 May 2021Editorial Decision: Accept