Conclusion and future perspective

An increase in life expectancy is the result of public health initiatives and successful infection control interventions. Reports indicate that 8 million people have been added to the world’s elderly population each year, and this increase will reach 24 million per year by 2030 (Nikolich-ugich et al., 2016).
At the molecular scale, aging is a result of collective damages to the biomolecular systems over a time span that could lead to various organ injury and physical and mental and subsequently contribute to age-related diseases that can impose high costs on the medical systems. Therefore, efforts to achieve treatment and medication methods that can prevent the disorders by targeting aging pathways will be worthwhile and valuable.
Consecutive to the advances in next-generation technologies, transcriptomic and proteomic, multiple genes involved in aging and longevity have been recognized in diverse organisms that disclose potential targets for designing novel anti-aging drugs. With the continued development of high-throughput screening (HTS) technologies and their application by pharmaceutical companies, enormous clinical medicines with a variety of therapeutic purposes are obtained from nanomaterials and their derivatives. Nanotechnology, along with chemical drugs and, in some cases, drugs of natural origin, has become very popular over the past ten years. Nanomaterials are widely used in the production of anti-aging skin medications in many cosmetics. Nanomedicines could act by directly modulating various signaling pathways, and function as anti-inflammatory, anti-apoptotic, autophagy regulatory, and genomic stabilizer compounds effect on aging progressing (Lin-Ping, Wang, & Li, 2019).
Nevertheless, it is evident that the evaluation of the anti-aging potential of nano-based compounds must include some pivotal assessments to mitigate the concerns on toxicity, modes of functions, interacting targets/pathways, effective and optimum dosage, clearance from the body, and finally, reproducibility and predictability of the interactions.
It is anticipated that the advancement in revealing the genetic and epigenetic molecular process of aging, along with the significant improvement in designing the safe nanomaterial, cooperatively can translate to a more reliable nano-based agent to fortify the longevity of human species.
Acknowledgements