AbstractYellow fever, a devastating disease, swept through the Lower Mississippi Valley in 1878, leaving a trail of death and despair. This study delves into the clinical history of this epidemic, drawing insights from the firsthand account of Dr. Thomas Osmond Summers, a seasoned medical professional. Our analysis reveals intriguing facets of the outbreak, shedding light on both medical practices and societal perceptions.Summers’ meticulous observations provide a glimpse into the grim reality faced by physicians during this crisis. His assertion that not all deaths were accurately recorded underscores the challenges in assessing the true mortality rate. Despite his flawed understanding of contagion, Summers’ work reflects prevailing beliefs of the time. The blame placed on frontline practitioners for inadequate reporting highlights the complexities of data collection during an epidemic.Interestingly, Summers avoids overt religious references, distancing his scientific account from personal faith. His focus on symptoms, diagnosis, and the disease’s progression offers valuable insights into the lived experience of yellow fever victims. The absence of class-based differences in mortality rates challenges assumptions about social stratification’s impact on disease susceptibility.In this historical puzzle, Summers’ account serves as a critical piece, allowing us to reconstruct the medical landscape and societal responses during a catastrophic epidemic. As we piece together this mosaic, we gain a deeper appreciation for the resilience of communities and the tireless efforts of medical professionals in the face of a relentless foe.This abstract encapsulates the epidemic’s nuances, emphasizing the interplay between science, society, and individual experiences. Further research can build upon Summers’ account to unravel additional layers of this compelling historical narrative.