Determinants UNDERDOSING Corrected p-value Adj. OR 95% CI Determinants OVERDOSING Corrected p-value Adj. OR 95% CI
All DOACs All DOACs All DOACs All DOACs All DOACs All DOACs All DOACs All DOACs
Age ≥80 years 0.43 0.83 0.56-1.21 Age ≥80 years 0.16 0.60 0.36-1.02
Benzodiazepines 0.34 1.22 0.84-1.78 Male sex 0.90 1.19 0.72-1.97
Diabetes 0.64 1.09 0.73-1.63 Surgery 0.16 0.61 0.35-1.06
CHA2DS2-VASc 0.08 1.17 1.05-1.30 CHA2DS2-VASc 0.43 0.92 0.76-1.10
Heart failure
0.55
1.12
0.77-1.64
Weight <60 kg ≥60 kg (REF)
<0.01
2.34
1.42-3.85
Weight <60 kg ≥60 kg (REF)
0.02
0.46
0.27-0.77
DOAC Dabigatran Apixaban Rivaroxaban (REF) 0.04 <0.01 0.24 0.18 0.08-0.71 0.10-0.32
DOAC Edoxaban Rivaroxaban (REF)
<0.01
0.42
0.24-0.74
Renal function (CrCl) <50 mL/min ≥50 mL/min (REF)
<0.01
11.29
6.23-20.45
Surgery 0.05 0.57 0.37-0.87
Narcotic analgesics 0.04 1.67 1.13-2.46
Bleeding history 0.02 1.86 1.24-2.80
Initiation at hospital <0.01 0.45 0.29-0.71
DABIGATRAN DABIGATRAN DABIGATRAN DABIGATRAN DABIGATRAN DABIGATRAN DABIGATRAN DABIGATRAN
Diabetes
0.14
2.79
0.94-8.29
Weight <60 kg ≥60 kg (REF)
0.27
4.14
0.48-35.49
Narcotic analgesics
0.06
3.52
1.23-10.12
Renal function (CrCl) <50 mL/min ≥50 mL/min (REF)
0.16
8.08
0.73-88.84
RIVAROXABAN RIVAROXABAN RIVAROXABAN RIVAROXABAN RIVAROXABAN RIVAROXABAN RIVAROXABAN RIVAROXABAN
Surgery 0.30 0.63 0.30-1.32 Age ≥80 years 0.16 0.43 0.16-1.14
Bleeding history
0.29
1.68
0.74-3.77
Weight <60 kg ≥60 kg (REF)
0.48
1.47
0.60-3.62
Initiation at hospital 0.08 0.21 0.05-0.91 CHA2DS2-VASc 0.26 0.82 0.62-1.09
Age ≥80 years
0.06
2.34
1.15-4.74
Renal function (CrCl) <50 mL/min ≥50 mL/min (REF)
<0.01
100.95
23.23-438.70
Renal function (CrCl) <50 mL/min ≥50 mL/min (REF)
<0.01
0.17
0.06-0.48
APIXABAN APIXABAN APIXABAN APIXABAN APIXABAN APIXABAN APIXABAN APIXABAN
Hypertension 0.46 1.32 0.72-2.43 Age ≥80 years 0.51 0.62 0.19-2.07
Diabetes
0.21
1.50
0.89-2.52
Weight <60 kg ≥60 kg (REF)
0.56
1.34
0.57-3.19
Renal function (CrCl) <50 mL/min ≥50 mL/min (REF)
0.08
1.80
1.06-3.04
Renal function (CrCl) <50 mL/min ≥50 mL/min (REF)
0.08
4.37
1.13-16.91
Heart failure 0.08 1.78 1.07-2.96 Surgery 0.26 0.25 0.03-1.92
Weight <60 kg ≥ 60 kg (REF)
<0.01
0.26
0.12-0.55
Heart failure
0.64
1.27
0.52-3.10
Bleeding history 0.03 2.14 1.22-3.75 CHA2DS2-VASc 0.90 0.98 0.68-1.41
HAS-BLED 0.26 1.42 0.85-2.35
EDOXABAN EDOXABAN EDOXABAN EDOXABAN EDOXABAN EDOXABAN EDOXABAN EDOXABAN
Surgery 0.20 0.36 0.10-1.33 Surgery 0.13 0.48 0.20-1.18
Initiation at hospital 0.12 0.36 0.12-1.03 CHA2DS2-VASc 0.23 0.79 0.58-1.08
HAS-BLED 0.90 0.96 0.52-1.77 HAS-BLED 0.56 1.02 0.64-1.63
CHA2DS2-VASc 0.08 1.48 1.02-2.14 Male sex 0.16 0.52 0.24-1.12
Narcotic analgesics
0.08
2.98
1.14-7.80
Weight <60 kg ≥ 60 kg (REF)
<0.01
4.16
1.97-8.77
Renal function (CrCl) <50 mL/min ≥50 mL/min (REF)
0.01
3.25
1.49-7.12