Author Contributions
Jian’an Huang and Weixing Zhang conceived the overall study. Xuefeng
Xia, Yanfang Guan, and Yuting Yi designed the study, Xiaorui Fu
constructed and managed the sequencing and variant-calling pipelines.
Xiaoxiong Xiao, Xiuqin Zhang, Zeyi Liu and Yue Li collected the samples
and clinical data. Jian Zhao analyzed the data. Xuan Gao aided in
statistical analyses. Jian Zhao wrote the manuscript. Xuan Gao and Han
Wang participated the optimization of the manuscript. All authors
contributed to writing the manuscript. All authors reviewed and approved
the final draft. Jian’an Huang and Weixing Zhang jointly supervised this
work.