Author Contributions
Jian’an Huang and Weixing Zhang conceived the overall study. Xuefeng Xia, Yanfang Guan, and Yuting Yi designed the study, Xiaorui Fu constructed and managed the sequencing and variant-calling pipelines. Xiaoxiong Xiao, Xiuqin Zhang, Zeyi Liu and Yue Li collected the samples and clinical data. Jian Zhao analyzed the data. Xuan Gao aided in statistical analyses. Jian Zhao wrote the manuscript. Xuan Gao and Han Wang participated the optimization of the manuscript. All authors contributed to writing the manuscript. All authors reviewed and approved the final draft. Jian’an Huang and Weixing Zhang jointly supervised this work.