Tumor infiltrating immune cells
At present, the majority of research on tumor immune microenvironment is tumor infiltrating immune cells, and almost All immune cell types can be found in the tumor microenvironment, including tumor associated macrophages (TAM), dendritic cells (DC), natural killer cells (NK), B lymphocytes (B cell), T lymphocytes (T cell), marrow-derived suppressor cells (MDSC), neutrophils, etc.[61]. The immune cells play an important role in shaping the TIME of EGFR mutant lung cancer by secreting cytokines and activating signal pathways (Figure 2).