3. Results
Kinetic of drug induced changes over the 24-hour post dosing recording period in all analysed parameters is shared as supplemental material 2. It includes a set of 20 hERG blocking drugs. Effects of 15 hERG blocking drugs with clinical reports of TdP (Redfern et al., 2003) are reported at the first dose level causing either QTc prolongation and/or increase in HFQT oscillations. This database also reports the effects of 5 non torsadogenic hERG blockers (including prasozin), milrinone and 6 other drugs interacting with the autonomic nervous system (atenolol, atropine, clonidine, hexamethonium, isoproterenol, phenylpherine, Supplemental Figures 106 to 126).