Human ECGs
Twenty-four-hour Holter recordings (2/3-lead configuration, sampling
rate: 200 Hz) were obtained from the Telemetric and Holter ECG Warehouse
(THEW, hosted at the University of Rochester Medical Center, NY, USA),
an initiative hosting a warehouse of digital Holter ECGs open to the
scientific community (Couderc 2012). The E-HOL-03-0202-003 database of
200 healthy subjects (age>15: 39±16, 100 females and 100
males) was analysed. Healthy subjects were considered as eligible for
enrollment and defined as healthy based on a battery of tests and
information including no history of cardiovascular disease or disorders
(stroke, TIA, peripheral vascular disease), no hasty of high BP
(>150/90 mmHg), no medication, no chronic illness, normal
physical examination, normal echocardiography, normal exercise testing
and no pregnancy. The E-HOL-03-0480-013 database of genotyped LQTS
patients was analysed for comparison with healthy subjects. Holter
recordings were analysed from 104 untreated LQT1 patients (age
> 15: 38±15, 60 females and 54 males) and 35 untreated LQT2
patients (age > 15: 37±15, 16 females and 19 males).