3. Results
Kinetic of drug induced changes over the 24-hour post dosing recording
period in all analysed parameters is shared as supplemental material 2.
It includes a set of 20 hERG blocking drugs. Effects of 15 hERG blocking
drugs with clinical reports of TdP (Redfern et al., 2003) are reported
at the first dose level causing either QTc prolongation and/or increase
in HFQT oscillations. This database also reports the effects of 5 non
torsadogenic hERG blockers (including prasozin), milrinone and 6 other
drugs interacting with the autonomic nervous system (atenolol, atropine,
clonidine, hexamethonium, isoproterenol, phenylpherine, Supplemental
Figures 106 to 126).