Results
The mean age of the patients was 66.9 ± 8.4 (44-88), PSA was 6.92 ± 1.85
(2.69-9.91), free PSA was 1.20 ± 0.52 (0.15-2.56), f/t PSA was 18.04 ±
8.1% (4-46), prostate volume was 53,6 ± 19.4 (18-108), and PSAD was
0.150 ± 0.078 (0.045-0.357). ISUP grade groups of the patients were 46
patients (59%) in grade group 1, 21 patients (26.9%) in grade group 2,
seven patients (9%) in grade group 3, four patients (5.1%) in grade
group 4, and zero patients in grade group 5. Thirty-two patients (41%)
had CSPCa (Gleason ≥ 7, ISUP group ≥2).
The P values of PSA, free PSA, PSAD, f/t PSA, and prostate volume
between CSPCa and N- CSPCa groups were 0.010, 0.780, 0.001, 0.084, and
0.030, respectively (Table 2).
The P values of PSA, free PSA, PSAD, f/t PSA, and prostate volume
between ISUP grade groups were 0.013, 0.850, 0.001, 0.379, and 0.022,
respectively (Table 3).
The area under the ROC curve (AUC) of the PSA and PSAD for predicting
CSPCa was 0.671 with a 95% Cl (0.549–0.793), 0.719 with a 95% Cl
(0.604–0.835), and the standard errors were 0.062 and 0.059,
respectively. When PSA cutoff was 6.29 for predicting CSPCa, sensitivity
and specificity were 78.1% and 50%, respectively. When PSAD cutoff was
0.130 for predicting CSPCa, sensitivity and specificity were 75% and
63%, respectively (Figure 1).