3.1 Literature Search
As shown in the flow chart in Figure 1, this study found a total of 846 relevant literatures through the database retrieval mentioned above.163 references were excluded due to duplication of content. After screening the title and abstract, 554 articles were excluded because they did not meet the eligible criteria. Then 76 articles were excluded according to the full text content, which combined with other interventions(n=30), review articles(n=6), non-RCT(n=4), with other early acute diseases(n=31), full text was not available(n=5). Finally, a total of 53 randomized controlled trials (RCTS) (3 English11-13and 50 Chinese14-63) that met the criteria were included for meta-analysis.