3.4.3 CRP clearance effect
Twenty-one studies compared the impact of CRRT group and control group on CRP clearance effect. Due to large heterogeneity (I2=96.4%), random effects model was used for analysis, and the results showed that the difference was statistically significant, that compared with the control treatment group, patients treated with CRRT had significantly higher CRP clearance effect. (WMD=-8.25, 95%CI-9.74 to -6.76, P<0.00001)(Fig.5). We conducted a subgroup analysis according to the clinical CRP value, and divided the CRP value 1-5 into a group, which was the normal value. CRP values of 5-50 were divided into a group, indicating the presence of mild and moderate inflammation in the body. CRP above 50 was divided into a group, suggesting severe inflammation in the body.