Studies
N (T/C) Gender (male/female) Mean age ± SD (years)
Cause of acute panScreatitis
time recorded point
outcome indicators
Xu GB et al. 2013
35/35
37/33
50. 3 ±7.9
biliary tract diseases:37 excessive drinking and eating:5 traumatic injury:5 unknown cause:5
NR
APACHE-II score,CRP,Length of ICU stay and mortality rate
Liu XS et al. 2017
22/53
T:14/8 C:31/22 T:(52.1±11.2) C:(50.7±13.4)
NR
24h 72h
HR, urine volume, K+,BUN,Scr,CRP,TNF-α, IL-6
Wang XQ et al. 2019
35/25
T:22/13 C:18/7 T:(40.5±9.5) C:(41.1±9.5)
hyperlipidemia
NR
Treatment effect,TG, CRP,blood amylase and urine amylase
Hui WJ et al. 2017
60/60
T:32/28 C:30/30 T:(37.6±5.4) C:(38.1±5.6)
NR
NR
Treatment effect, blood amylase, TNF-α, IL-1
Zou YD et al. 2017
31/31
T:18/13 C:16/15 T:(43.02±4.51) C:(43.85±3.91)
NR
NR
Treatment effect, blood amylase, CRP, IL-6,PO2
Deng ZY et al. 2014
32/32
46/18
41.7
biliary panScreatitis:47 alcoholic panScreatitis:12 unknown cause:5
NR
APACHE-II score,TNF-α, endotoxin, IL-6, IL-18, mortality rate
Peng Y et al. 2019
22/20
25/27
37
biliary tract diseases:18 excessive drinking and eating:11 mixed cause:10 idiopathic cause:3
NR
IL-6,TNF-α, blood amylase
Zhong X et al. 2017
37/37
T:23/14 C:21/16 T:(56.5±4.3) C:(55.8±4.4) T: biliary tract diseases:14 excessive drinking and eating:8 alcoholism:9 other cause:6 C: biliary tract diseases:15 excessive drinking and eating:7 alcoholism:8 other cause:7
72h
Treatment effect, APACHE-II score,ALB,ALT, 24h urine output ,BUN,Scr
Peng B et al. 2019
41/41
T:27/14 C:26/15 T:(43.7±8.6) C:(44.3±8.5) T: biliary tract diseases:19 hyperlipidemia:8 alcoholism:10 other cause:4 C: biliary tract diseases:17 hyperlipidemia:9 alcoholism:10 other cause:5 6h 12h 24h
PCT,CRP, D-dimer, blood lipase,blood amylase,PLT
Zou H.2018
22/15
T:20/2 C:4/11 T:(39.23±6.36) C:(38.27±6.77)
hyperlipidemia
48h
Treatment effect,TG,TCH, blood lipase,blood amylase,CRP,Scr
Wang Y et al. 2018
36/36
T:24/12 C:25/11 T:(47.4±13.6) C:(46.7±13.2) T: biliary tract diseases:19 excessive drinking and eating:7 alcoholism:10 other cause:4 C: biliary tract diseases:11 excessive drinking and eating:10 alcoholism:6 other cause:7 24h 72h
CRP, PCT, Scr, BUN, Ca, APACHE-II score
Ni ZH.2013
29/22
T:21/8 C:10/12 T:(47.3±14) C:(47.18±12.24) T: biliary tract diseases:8 excessive drinking and eating:8 alcoholism:8 unknown cause:5 C: biliary tract diseases:7 excessive drinking and eating:3 alcoholism:5 unknown cause:7 24h 48h 72h 24h urine output,PH,PO2,PCO2, BUN,SCr,Na,K,Ca,ALT,WBC, Treatment effect
Li YN et al. 2002
20/17
25/12
43.3
biliary tract diseases:7 excessive eating:6 alcoholism:10 unknown cause:3 Trauma:2
7days
Treatment effect, blood amylase,SCr,TP,ALB,GLU,Ca
Chen DJ et al.2018
49/49
T:26/23 C:24/25 T:(45.72±6.34) C:(46.52±7.35)
NR
12h 24h 36h
HR, 24h urine output,PO2,PCO2,PH,Ca,K,Na,BUN,SCr,GLU,ALT,PLT,WBC
Tian JX et al.2015
60/60
T:35/25 C:36/24 T:(42.9±12.5) C:(43.8±11.7)
NR
72h
APACHE-II score, blood amylase,ALB,TP
Li Q.2020
27/27
T:15/12 C:14/13 T:(45.39±5.56) C:(45.66±5.79) T: biliary calculi:4 alcoholism:7 sphincter dysfunction of hepatopancreatic ampulla:3 hyperlipidemia:3 excessive drinking and eating:10 C: biliary calculi:3 alcoholism:8 sphincter dysfunction of hepatopancreatic ampulla:4 hyperlipidemia:3 excessive drinking and eating:9
72h
APACHE-II score, Treatment effect
Xiao XP.2014
17/13
18/12
48±5
NR
24h 48h 72h
Treatment effect,TNF-α
Zhu JG et al.2007
17/14
T:10/7 C:9/5 T:(49.93±10.3) C:(51.05±11.10)
NR
NR
HR,PCT,CRP, Treatment effect
Wang LY.2017
45/45
T:28/17 C:25/20 T:(46.25±5.63) C:(48.53±6.24)
NR
NR
APACHE-II score,CRP,PCT, TNF-α
Yang H.2013 25/25 27/23 43.25 NR NR APACHE-II score,SCr,TG, blood amylase ,PO2,ALT
Li KY.2016
30/30
T:20/10 C:16/14
NR
NR
24h 72h 7days
HR,APACHE-II score,CRP,PCT, TNF-α,BUN,SCr,ALT,AST
Cui WY et al.2017
16/11
T:10/6 C:4/7 T:(49.91±24.23) C:(50.63±14.30) T: biliary tract diseases:8 alcoholism:2 hyperlipidemia:5 other cause:1 C: biliary tract diseases:7 alcoholism:2 hyperlipidemia:2 other cause:0 24h 72h
SCr,WBC,CRP
Chen FS.2020 45/45 45/45 45±6.7 NR 48h SCr,PCT,TG,TB,pH,PO2,HR, blood amylase
Xu F et al.2019
32/32
T:19/13 C:18/14 T:(42.05±3.93) C:(42.68±2.95) T: biliary tract diseases:14 alcoholism:13 hyperlipidemia:5 C: biliary tract diseases:15 alcoholism:12 hyperlipidemia:5
72h
HR,BUN,SCr,ALT,AST, blood amylase
Zhu CZ.2016
40/40
T:25/15 C:28/12 T:(45.2±8.5) C:(44.9±7.9)
NR
72h
PO2,PCO2,WBC,HR
Gao N. et al.2018
46/46
T:24/22 C:22/24 T:(38.87±6.47) C:(39.13±6.56) T: alcoholism:16 hyperlipidemia:20 cholelithiasis:7 other cause:3 C: alcoholism:14 hyperlipidemia:18 cholelithiasis:9 other cause:5 6h 12h 24h
PCT,CRP,IL-17,IL-6,HMGB1,D-dimer
Xu JM. et al.2017
25/11
T:24/22 C:22/24
NR
NR
7days
blood amylase,ALT,SCr,CRP,Hb,ALB,Ca,WBC,INR
Chen X et al.2019
32/28
T:20/12 C:18/10 T:(54.32±10.65) C:(58.94±9.02)
NR
7days
ALT,AST, TBIL,ALB,WBC,RBC,PLT,BUN,SCr, blood and urine amylase
Zhang X.et al.2016 8/14 14/8 54±14 NR 48h APACHE-II score,TG,CRP, Treatment effect
Wang LF.2020
15/15
T:8/7 C:7/8 T:(46.7±11.4) C:(46.8±11.5)
NR
72h
Na,Ca,K,BUN,Scr,WBC,PLT,ALT,TBIL,HR, 24h urine output
Liu MX.et al.2011 15/15 10/16 53±16 NR 48h APACHE-II score,TG,CRP, blood and urine amylase, Treatment effect
Xu JY.2013 12/20 23/9 47.5 hyperlipidemia 48h Treatment effect, APACHE-II score,TG,CRP,blood and urine amylase
Wu SK.2015
28/30
T:18/10 C:19/11 T:(67.5±10.3) C:(69.5±11.3) T: alcoholism:8 cholelithiasis:10 other cause:10 C: alcoholism:10 cholelithiasis:12 other cause:8
NR
Treatment effect, the time taken for clinical indicators to return to normal
Xu Y.et al.2009
30/30
T:20/10 C:19/11 T:(30±10.5) C:(43.1±10.5) T: alcoholism:6 high-fat diet:6 history of biliary tract infection:5 excessive drinking and eating:12 unknown cause:1 C: alcoholism:6 high-fat diet:5 history of biliary tract infection:8 excessive drinking and eating:9 unknown cause:2 24h 48h 72h
APACHE-II score
Wei R.2016
40/40
NR
60.3±1.8
alcoholism:37 cholelithiasis:43
NR
APACHE-II score,HR,MAP,CRP,BUN,AST
Tian GX.2016
60/60
T:32/28 C:30/30 T:(37.6±5.4) C:(38.1±5.6)
NR
NR
Treatment effect,IL-1,TNF-α,blood amylase
Wan CS.2017
60/60
NR
NR
T: alcoholism:18 cholelithiasis:13 excessive drinking and eating:24 unknown cause:5 C: alcoholism:20 cholelithiasis:15 excessive drinking and eating:21 unknown cause:4
72h
Na,K,Ca,BUN,SCr,WBC,PLT,ALT,TBIL,HR, 24h urine output
Wang YF.et al.2017
12/20
T:7/5 C:14/6 T:42 C:41
hyperlipidemia
NR
HR,SCr,TG,CRP,IL-1,TNF-α,GLU, APACHE-II score
Ji HL.et al.2011
36/38
T:23/13 C:25/13 T:57 C:54
NR
NR
CRP,APN, Treatment effect
Li LL.2018
40/40
T:23/17 C:25/15 T:(43.26±8.87) C:(42.17±8.67)
NR
72h
IL-6,TNFα,SCr,BUN, Treatment effect
Li YP.2014
13/13
T:9/4 C:9/4 T:51.8 C:56.5 alcoholism:8 cholelithiasis:3 excessive drinking and eating:10 hyperlipidemia:2 surgery:1 hepatopancreatic ampulla sphincter dysfunction:2
7days
IL-6,TNF-α,WBC,HR,CRP,PH,PO2 ,Treatment effect
Li QB.et al.2009
19/19
T:12/7 C:14/5 T:(44.3±19.5) C:(45.4±18.7) T: cholelithiasis:10 excessive drinking and eating:5 trauma:2 unknown cause:2 C: cholelithiasis:13 excessive drinking and eating:6
72h
IL-6,TNF-α, APACHE-II score,PO2,PH, Treatment effect
Hu W.et al.2001
10/10
T:7/3 C:7/3 T:(56.8±15.4) C:(59.7±13.2)
NR
7days
IL-6,TNF-α,IL-1β,APACHE-II score,Treatment effect
Shen Q.et al.2016
43/35
47/31
47.3±14.8
cholelithiasis:23 excessive drinking and eating:13 alcoholism:18 hyperlipidemia:15 unknown cause:9
72h
APACHE-II score, TNF-α,CRP, Treatment effect, blood amylase
Sun JH.et al.2018
39/39
T:22/17 C:24/15 T:(40.4±5.9) C:(43.6±6.9)
NR
24h
HR,BUN,SCr,ALT,AST, blood amylase
Wu LM.et al.2013
40/18
T:17/23 C:11/7 T:(50.5±9.4) C:(51.4±7.8) cholelithiasis:43 hyperlipidemia:13 other cause:2
72h
APACHE-II score,TBIL,SCr,Ca,GLU,WBC
Liu JQ.2019
50/50
T:27/23 C:26/24 T:(42.3±6.5) C:(42.1±7.1) T: cholelithiasis:11 hyperlipidemia:17 alcohol abuse:14 other cause:8 C: cholelithiasis:13 hyperlipidemia:15 alcohol abuse:16 other cause:6
72h
PO2,WBC,MAP,Na,K,PCT,CRP
Hou QC.et al.2018
36/36
T:20/18 C:22/16 T:(42.3±6.5) C:(45.6±3.6)
NR
NR
APACHE-II score,CRP,PCT,TNF-α
Zhou JY.2015
23/23
T:13/10 C:12/11 T:(46.7±8.7) C:(47.2±9.1) T: cholelithiasis:12 hyperlipidemia:4 alcohol abuse:6 other cause:1 C: cholelithiasis:10 hyperlipidemia:4 alcohol abuse:7 other cause:2
NR
CRP,PCT,SCr,BUN,ALT,ALB
Yu ZD.et al.2015
25/25
T:18/7 C:12/13
NR
biliary tract :25 cholelithiasis with cholecystitis:10 high-fat diet:7 alcohol abuse:3 overeating:3 unknown cause:2
NR
APACHE-II score,CRP
Wang XM.2016
50/50
T:28/22 C:26/24 T:(48.5±8.4) C:(45.4±6.2)
NR
NR
PO2,PH
Tang W.et al.2017
35/35
T:21/14 C:20/15 T:(45.6±13.1) C:(46.7±12.9) T: alcoholism:8 cholelithiasis:7 excessive drinking and eating:6 hyperlipidemia:6 hepatopancreatic ampulla sphincter dysfunction:8 C: alcoholism:5 cholelithiasis:9 excessive drinking and eating:6 hyperlipidemia:7 hepatopancreatic ampulla sphincter dysfunction:8
48h
TG,TB,SCr,PCT,PH,PO2,AMS
Peng Y.et al.2017 40/40 48/32 34 NR NR Il-1β,TNF-α,PCT,AMS,HR, APACHE-II score, Treatment effect