Correlation between Intra-operative fs-ABR and Follow-up PTA
Result
Among the forty-two CHL patients (16 males and 26 females), 15 subjects
were tested by S3 and 27 by S1. Thirty-seven patients (88.10%)
completed the 6-month follow-up. Two subjects of S3 group and 3 subjects
of the S1 group were excluded from the analysis because of living remote
from the hospital (Supplemental Table3). The ABG improvement (ABGI),
fs-ABRI and PTAI were was the difference of pre- and post-surgery ABG,
fs-ABR and PTA.
For all 42 CHL subjects, the post-surgery PTA(1kHz) and
PTA(0.5/1/2kHz) was 37.65±18.06 dB HL and 38.52±16.67 dB
HL with the average HI of 19.41±21.2 dB and
13.37±21.74
dB, respectively. The post-surgery ABG at 1kHz
(ABG(1kHz)) and 0.5/1/2kHz
(ABG(0.5/1/2kHz)) was 25.15±14.93 dB and 19.15±15.39dB
with an average ABGI of
18.97±18.66
dB and 22.79±18.21dB respectively. Bland Altman analysis showed no
difference between the two methods for
PTA(1kHz)(Figure4B) and
PTA(0.5/1/2kHz)(FigureS2A). The linear relation was
PTA(1kHz) (Y) =0.58* intra-fs-ABR +9.56 (r =0.42,p =0.014<0.05) and PTA(0.5/1/2kHz)=0.44* intra-fs-ABR +17.44 (r =0.34,p =0.04<0.05). PTAI(1kHz)=1.31*fs-ABRI+1.74 (r =0.48,p <0.01) and
PTAI(0.5/1/2kHz)=1.44*fs-ABRI-2.956
(r =0.52,p <0.01) (FigureS2).
For S1, post-surgery PTA(1kHz),
PTA(0.5/1/2kHz), ABG(1kHz) and
ABG(0.5/1/2kHz) were 36.67±19.13dB HL, 37.22±17.53dB HL,
24.5±15.3dB and 19.11±14.67dB respectively; for S3, 37.92±16.85dB HL,
41.92±16.17dB HL, 26.15±14.88dB and 21.54±11.42dB respectively.
Two-sided unpaired T test showed no statistical difference between group
S1 and S3 post-surgery PTA follow-up results for each above parameter
(p =0.68, p =0.95, p =0.38, p =0.95
respectively) (Figure4A).
For S1 and S3, Bland-Altman analysis showed no difference between two
methods for both PTA(1kHz) and
PTA(0.5/1/2kHz). In S1,
PTA(1kHz)=1.22*intra-fs-ABR-30.35 with r =0.5
(p =0.02<0.05) and
PTA(0.5/1/2kHz)=1.01*intra-fs-ABR-18.37 withr =0.46 (p =0.03<0.05).
PTAI(1kHz)=2.15* fs-ABRI-3.49 with r =0.67
(p =0.0063<0.01) for and
PTAI(0.5.1.2kHz)=2.43*fs-ABRI-8.76 with r =0.69
(p =0.0042<0.01) (Figure4 and FigureS2). In S3,
PTA(1kHz) =0.93*intra-fs-ABR+3.48 with r =0.76
(p =0.0026<0.05) and
PTA(0.5/1/2kHz)=0.83*intra-fs-ABR+9.92 withr =0.71 (p =0.0068<0.01). For PTAI and fs-ABRI, p
value was 0.22 and 0.1 for PTA(1kHz) and
PTA(0.5/1/2kHz) respectively (Figure4E and FigureS2D).