Figure 2. BW-031 inhibition of human Nav1.1 and Nav1.8 channels.
a, Use-dependent inhibition of hNav1.1 channels
by 100 µM intracellular BW-031 (red) compared to recording with control
intracellular solution (black). Nav current was evoked
by 20-ms depolarizations from -100 to 0 mV at the indicated frequencies.b, Collected results for hNav1.1 inhibition by
100 µM intracellular BW-031 (red, n=5) compared with control (black,
n=5) and with inhibition of hNav1.7 (n=6, replotted from
Figure 1e) c, Use-dependent inhibition of
hNav1.8 channels by 300 µM intracellular BW-031 (red)
compared to recording with control intracellular solution (black).
Nav current was evoked by 20-ms depolarizations from -70
to 0 mV at the indicated frequencies. d, Collected results
(mean±SEM) of hNav1.8 inhibition by 300 µM intracellular
BW-031 (red, n=5) compared with control (black, n=5) and with inhibition
of hNav1.7 by 100 µM BW-031 (n=6, replotted from Figure
1e) Data are mean±SEM and statistics are calculated from two-tailed
Mann-Whitney Test. ns p>0.05, *p<0.05, and
**p<0.01.