Results
Table 1 shows baseline characteristics of the patients with GFR
<60 ml/min (renal dysfunction) compared with patient with GFR
≥60 ml/min. Over 98% of the patient population were either African
Americans or Latinos. Table 1 also shows the statistically significant
differences in baseline characteristics. Table 2 shows incidence of
myocardial Ischemia, stroke, and MI stroke or death in patients with
renal dysfunction as compared to patients with GFR ≥60. Out of 339
patients with renal dysfunction, 56 (17%) had MI, 72 (21%) had stroke,
85 (25%) died and 163 (48%) had MI, Stroke or Death. In comparison,
out of 317 patients with GFR ≥60, 27 (9%) patient had MI, 48 (15%) had
stroke, 41 (13%) died and 99 (31%) had MI, stroke or death. Table 3
shows stepwise cox regression analysis for the time to the development
of MI, Stroke, Death and MI, stroke or Death (any event).
Renal dysfunction was an independent risk factor for MI (Hazard ratio
1.88 (1.17, 3.04); p=0.009). It also shows CAD is an independent risk
factor for MI (2.79 (1.78, 4.39); p<0.001) as shown in prior
studies. Renal dysfunction is an independent risk factor for death (HR
1.63 (1.11, 2.41); p=0.014). In addition, age (HR 1.31 (1.13, 1.51), P
value <0.001) and prior MI (HR 2.24 (1.46, 3.43);
p<0.001) are also independent risk factors for death as shown
in prior studies. Where renal dysfunction is not an independent risk
factor for stroke (HR 1.13 (0.77, 1.65); p=0.529), age (HR 1.31 (1.13,
1.51); p<0.001) and prior stroke (HR 1.99 (1.36, 2.92),
p=0.001) are independent risk factors for new stroke as demonstrated in
prior studies. Renal dysfunction is an independent risk factor for MI,
stroke or death (Hazard ratio 1.37 (1.05, 1.78); p=0.018). It also shows
that age (HR 1.32 (1.20, 1.46); p<0.001) and prior stroke (HR
1.47 (1.11, 1.94); p=0.007) are also an independent risk factors for
composite of these three events.