Patient Population
The study is a retrospective chart review of consecutive patients treated for Acute Lymphoblastic Leukemia at the CCI. Children and adolescents aged 1-21 years who were diagnosed between October 2007 and February 2018 were included. Patients who developed CSVT during treatment were identified. Relevant information such as patient characteristics, treatment regimen and clinical outcome were collected and compared between two groups: patients who developed CSVT during treatment versus those who did not. CT venography and/ or MRI were used to diagnose CSVT.
This study builds on a previous one done at our institution that described certain potential risk factors for the development of CSVT in children being treated for ALL. It showed that age above 10 years at diagnosis, T-cell immunophenotype and risk stratification (intermediate/high risk) were statistically significant risk factors for CSVT [4].
Our study was reviewed and approved by the Institutional Review Board at the American University of Beirut Medical Center.