Risk factors:
With univariate analysis, male gender (p = 0.004), age> 10 years at diagnosis (P = 0.002), T-cell
immunophenotype (P = <0.0001), intermediate/high-risk
disease (P = 0.05), maximum triglyceride (TG) levels of
> 615 mg/dL (p = 0.012), presence of mediastinal
mass (P = <0.0001), and body surface area (P =<0.0001) were significantly associated with increased risk of
CSVT. On the other hand, initial blast count (P = 0.765), non-O
blood group (P = 0.843) and BMI (P = 0.209) were not
significantly associated with increased risk of CSVT.
With multivariate analysis using Cox regression model considering age at
diagnosis, gender, immunophenotype, risk stratification, mediastinal
mass, BSA, BMI, and maximal TG level as variables,
intermediate/high-risk disease (OR: 6.879, 95% CI: 1.235–38.304,P = 0.028), presence of mediastinal mass (OR: 23.949, 95% CI:
5.606–102.316, P = 0.000), maximum TG levels of >
615 mg/dL (OR: 3.732, 95% CI: 1.007–13.836, P = 0.049) and larger BSA
(1 unit increase as a continuous variable) (OR: 6.234, 95% CI:
1.694–22.921, P = 0.006) were the only statistically significant
risk factors. Detailed results are shown in Table 2.