Risk factors:
With univariate analysis, male gender (p = 0.004), age> 10 years at diagnosis (P = 0.002), T-cell immunophenotype (P = <0.0001), intermediate/high-risk disease (P = 0.05), maximum triglyceride (TG) levels of > 615 mg/dL (p = 0.012), presence of mediastinal mass (P = <0.0001), and body surface area (P =<0.0001) were significantly associated with increased risk of CSVT. On the other hand, initial blast count (P = 0.765), non-O blood group (P = 0.843) and BMI (P = 0.209) were not significantly associated with increased risk of CSVT.
With multivariate analysis using Cox regression model considering age at diagnosis, gender, immunophenotype, risk stratification, mediastinal mass, BSA, BMI, and maximal TG level as variables, intermediate/high-risk disease (OR: 6.879, 95% CI: 1.235–38.304,P = 0.028), presence of mediastinal mass (OR: 23.949, 95% CI: 5.606–102.316, P = 0.000), maximum TG levels of > 615 mg/dL (OR: 3.732, 95% CI: 1.007–13.836, P = 0.049) and larger BSA (1 unit increase as a continuous variable) (OR: 6.234, 95% CI: 1.694–22.921, P = 0.006) were the only statistically significant risk factors. Detailed results are shown in Table 2.