Clinical outcomes
Eighteen out of the 21 (85.7%) vaccinated patients neither developed COVID-19-infection symptoms nor tested positive following a risk contact with a SARS-CoV-2-infected person. COVID-19 infection was confirmed in three (14.3%) vaccinated patients with CVID (two females and one male; 38.33±7.57 years; range: 33–47 years) at the end of the follow-up period at month 6 (November 2021). Two of them had CVID-associated non-infectious complications (splenomegaly, chronic enteropathy, and autoimmune thyroiditis). The infection was mild in all three patients. The major symptoms were fever, arthralgia, and myalgia, which were present in all patients. Two patients reported cough, rhinitis, gastrointestinal symptoms, and fatigue. One patient developed a loss of smell. None of the patients required antiviral treatment or hospital admission. Two of them were classified as responders to vaccination; however, the humoral response persisted in a single patient at month 3. The three patients did not have a cellular response.