METHODS
This is a study of 8 hospitalized patients because the confirmed covid-19 in their parents in the time of beginings of pandemic and when it has existed the fear of severe covid19 in children and when the covid19 in children was an absolutely unknown disease. The short time after that, we didn’t hospitalized the asymptomatic children (carriers of SARS-CoV2) which justifies a small sample. Inclusion criteria were: 1) children up to 14 years of age, 2) laboratory confirmed SARS-CoV2 viral infection by PCR technique from nasopharyngeal swab, on admission in clinic, 3) asymptomatic patients on the day of admission in clinic and during 14 days of hospitalization, 4) performed basic hematological, biochemical and radiographic diagnostics, on admission in clinic. The diagnosis of asymptomatic COVID-19 was made on the basis of the Guidelines for the Diagnosis and Treatment of Novel Coronavirus Pneumonia (6th Trial Edition) proposed by the National Health Commission of the People’s Republic of China5. The basic hematological values contained a complete blood count6. The basic biochemical values included transaminases (SGOT, SGPT) and lactate dehydrogenase (LDH), and as basic inflammatory marker was determined a C-reactive protein (CRP)6.
In all asymptomatic subjects, on admission to the hospital, the PCR test for SARS-CoV-2 was positive. During 14 days of follow-up of asymptomatic subjects, the PCR test for SARS-CoV-2 became negative. From all subjects, we obtained data on a positive epidemiological history of SARS-CoV-2 virus infection, i.e. all subjects had one or more family members with positive PCR test for SARS-CoV-2. Observed signs and symptoms of SARS-CoV-2 infection were fever, cough, sore throat, shortness of breath, difficulty breathing, smell and taste dysfunction, sneezing, stuffy or runny nose, fatigue and tiredness, body aches, headache, diarrhea, vomiting, abdominal pain, conjunctival injection, watery eyes, mucous membrane changes, lymphadenopathy, and rash. The research was conducted in accordance with the Ethics Committee.