METHODS
This is a study of 8 hospitalized patients because the confirmed
covid-19 in their parents in the time of beginings of pandemic and when
it has existed the fear of severe covid19 in children and when the
covid19 in children was an absolutely unknown disease. The short time
after that, we didn’t hospitalized the asymptomatic children (carriers
of SARS-CoV2) which justifies a small sample. Inclusion criteria were:
1) children up to 14 years of age, 2) laboratory confirmed SARS-CoV2
viral infection by PCR technique from nasopharyngeal swab, on admission
in clinic, 3) asymptomatic patients on the day of admission in clinic
and during 14 days of hospitalization, 4) performed basic hematological,
biochemical and radiographic diagnostics, on admission in clinic. The
diagnosis of asymptomatic COVID-19 was made on the basis of the
Guidelines for the Diagnosis and Treatment of Novel Coronavirus
Pneumonia (6th Trial Edition) proposed by the National Health Commission
of the People’s Republic of China5. The basic
hematological values contained a complete blood
count6. The basic biochemical values included
transaminases (SGOT, SGPT) and lactate dehydrogenase (LDH), and as basic
inflammatory marker was determined a C-reactive protein
(CRP)6.
In all asymptomatic subjects, on admission to the hospital, the PCR test
for SARS-CoV-2 was positive. During 14 days of follow-up of asymptomatic
subjects, the PCR test for SARS-CoV-2 became negative. From all
subjects, we obtained data on a positive epidemiological history of
SARS-CoV-2 virus infection, i.e. all subjects had one or more family
members with positive PCR test for SARS-CoV-2. Observed signs and
symptoms of SARS-CoV-2 infection were fever, cough, sore throat,
shortness of breath, difficulty breathing, smell and taste dysfunction,
sneezing, stuffy or runny nose, fatigue and tiredness, body aches,
headache, diarrhea, vomiting, abdominal pain, conjunctival injection,
watery eyes, mucous membrane changes, lymphadenopathy, and rash. The
research was conducted in accordance with the Ethics Committee.