Gene Effect on ALS Method/Model Subtype of ALS Reference
EPHA4
Survival, onset Loss of function increases survival Mice, zebrafish, patients Pharmacological inhibition increases survival Loss of function mutations long survival TDP-43A315T zebrafish SOD1A4V, SOD1G93A, SOD1G37R zebrafish Tg-SOD1G93AEphA+/- mice Pharmacological targeting in Tg-SOD1G93A-rat
TDP-43, SOD1
Van Hoecke et al., 2012
EPHA4 Extends survival Pharmacological targeting in Tg-SOD1G93A mice SOD1 Wu et al., 2017
EPHA4 Delays onset Tg-PFN1G118V mice PFN Ling et al. 2018
CX3CR1 Survival Patients Lopez-Lopez et al., 2014
CX3CR1 Survival, knockout reduces survival TgSOD1G93A Cx3cr1-/- mice SOD1 Liu et al., 2019
IL6R
C variant Asp358Ala Increased rate of progression
Patients
Wosiski-Kuhn et al., 2019
KCNJ11
Survival
Patients Rs5219 increased survival in bulbar ALS, patients with T/T survived longer
Vidal-Taboada et al., 2018
ABCC8
Survival
Patients Rs4148646 increased survival in bulbar ALS patients with G/G survived longer, Rs4148642 In spinal ALS patients with C/C have increased progression rate
Vidal-Taboada et al., 2018
UNC13A
Survival Regulates neurotransmitter release Patients Rs12608932 shorter survival
Diekstra et al., 2012