Naive B cells constitute major B cell population in TA patients
Cluster 3 (B cell) and Cluster 9 (pDC) were further subdivided into 5 B cell subgroups (B0–4) for analysis (Figure 4a) . B0 (IGKC) were classified as naïve B cells (Figure 4b, c) (20) . B1 subcluster also contained genes with low expression except IGLC2, IGLC3, other immunoglobulin genes and were also categorized as Naive B cells(20). B2 subclusters were classified as plasmacytoid DCs (pDCs) (Figure 4c) (20, 21) with genes responsible for signal transduction and cytokine secretion (ITM2C, IRF7, LILRA4, and CCDC50). B3 was classified as Plasma B-cells (Figure 4c )(31) and contained genes (BPTF, NEAT1, and GOLGA4) regulating transcription, protein transport, and protein modification(32-34) and B4 was classified as unknown.