Chip characterization
A two-turn spiral channel with a rectangular cross-sectional geometry
was first designed and tested by Bhagat et al. 58 to
isolate CTCs from blood. A similar design was used to study the behavior
of particles of different sizes in our work. The design is shown in Fig.
1 in the center. The microchannel had a width of w = 500 µm and a
height of h = 50 µm. The aspect ratio, defined as width/height
(w/h) was 10. The blockage ratio, which is defined as a/h, where ‘a’ is
the diameter of the particle and ‘h’ is the channel height, ranged from
0.02 to 0.14.