Patient Demographics
Between November 2010 and 2019, 281 patients with TM underwent HCT in our centre. Of these, patients who gave consent to participate in the study, as well as those with follow-up, were enrolled for the PK study (n=169). There was no significant difference in demographics between the patients with high-risk TM enrolled in the PK study compared to the total number of patients with high-risk TM who underwent HCT during the study period. (Table-S2) Two hundred and eighty-one patients with high-risk TM underwent HCT with Thio/F-araA/Treo conditioning regimen during the study period. Their median age was 9yrs (1-25yrs). Majority of the patients belonged to class III (Class III High Risk-48%; class III Low risk-39%) and 12% of patients belonged to class II. The demographics of these patients are summarized in Table 1.