Methods
All patients with TM who receiving F-araA based regimen prior to HCT
between September 2010 and 2019 were enrolled in this study. F-araA
plasma levels were analyzed using LC-MS/MS. Selected polymorphisms in
genes encoding for the enzymes (NT5E (Ecto-5’-nucleotidase) andDCK (Deoxycytidine kinase) involved in the metabolism of F-araA
were screened. The influence of F-araA PK and PG on clinical outcomes
were evaluated.